NKX2-3 and SRF

Data Source:
HPRD (in vivo)

		NKX2-3	SRF
Description		NK2 homeobox 3	serum response factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Cellular_component Nucleus	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Leukocyte Homeostasis Plasma Cell Differentiation Regulation Of Transcription By RNA Polymerase II Triglyceride Metabolic Process Biological_process Gland Morphogenesis Cell Differentiation Macrophage Differentiation Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Lymph Node Development Spleen Development Peyer's Patch Development Post-embryonic Digestive Tract Morphogenesis Leukocyte Migration	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Cell-matrix Adhesion Heart Development Long-term Memory Negative Regulation Of Cell Population Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Positive Regulation Of Transcription Via Serum Response Element Binding Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Actin Cytoskeleton Organization Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Thyroid Gland Development Neuron Projection Development Regulation Of Water Loss Via Skin Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Thymus Development Developmental Growth Neuron Development Erythrocyte Development Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Long-term Synaptic Depression Face Development Heart Trabecula Formation Lung Morphogenesis Bronchus Cartilage Development Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Lung Smooth Muscle Development Bicellular Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways			RHO GTPases Activate Formins NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 25990418 30529582 24737748) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 25489960 28067908 17554261 22412388 17554300 21102463) Dental caries ( 23064961) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hypothyroidism ( 27182965) Inflammatory bowel disease ( 28067908 23128233) Leukocyte telomere length ( 31171785) Mean corpuscular hemoglobin ( 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Red blood cell traits ( 23222517) Ulcerative colitis ( 28067908 20228798 20228799)
Interacting Genes		3 interacting genes: GTF2A1L SRF ZNF212	71 interacting genes: ALDH3A1 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 FOXG1 FOXK1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MRTFA MRTFB MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARA REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 TRIP4 UBE2I ZIC3
Entrez ID		159296	6722
HPRD ID		05992	02788
Ensembl ID		ENSG00000119919	ENSG00000112658
Uniprot IDs		Q8TAU0	A0A024RD16 B4DU24 P11831
PDB IDs			1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?
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