CYP21A2 and KRTAP4-2

Data Source:
BioGRID (two hybrid)

		CYP21A2	KRTAP4-2
Description		cytochrome P450 family 21 subfamily A member 2	keratin associated protein 4-2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Cytosol Keratin Filament
	Molecular Function	Steroid 21-monooxygenase Activity Steroid Binding Iron Ion Binding Steroid Hydroxylase Activity Heme Binding 17-hydroxyprogesterone 21-hydroxylase Activity Progesterone 21-hydroxylase Activity	Protein Binding Identical Protein Binding
	Biological Process	Steroid Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Sterol Metabolic Process	Keratinization
Pathways		Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Keratinization
Drugs		Ketoconazole
Diseases		Congenital adrenal hyperplasia (CAH) 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Diastolic blood pressure ( 25249183) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hypertension ( 25249183) Inflammatory bowel disease ( 28067908) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043) Prostate cancer ( 23535732) Systolic blood pressure ( 25249183) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908)
Interacting Genes		18 interacting genes: CRCT1 CREB5 CYSRT1 HOXA1 KRTAP1-3 KRTAP4-2 KRTAP9-2 LCE1F LCE2C LCE3B LCE3C LCE5A NBPF19 NOTCH2NLA NR4A3 PICK1 POTEB3 POU4F2	124 interacting genes: ADAMTSL4 ALDH3B1 AMOTL2 ANKS1A AQP1 ATG9A AVPI1 AXIN1 BAG4 BYSL CATSPER1 CCER1 CELF5 CHIC2 CHRD CRCT1 CREB5 CRY2 CYP21A2 CYSRT1 DLGAP2 DOCK2 FAM74A4 GLRX3 GNMT GUCD1 HOXA1 HOXB9 HPCAL1 HSD3B7 ITGB4 KPRP KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP26-1 KRTAP3-3 KRTAP4-4 KRTAP4-5 KRTAP5-2 KRTAP5-3 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 MAFB MEOX2 NBPF19 NECTIN3 NLK NOTCH2NLA NR1D2 NR4A3 NTAQ1 NUFIP2 OTX1 OXER1 PDE9A PGLS PHLDA1 PIN1 PLSCR1 PLSCR4 POM121L8P POU4F2 PRKAB2 PRKAG1 PSMA6 RASSF5 RGS20 SDC3 SHFL SLC23A1 SLC25A10 SMCP SPATA24 SPATA3 SPRY1 TCEANC TINAGL1 TRIM42 TXNDC5 TYRO3 VASN VGLL3 YY1 ZBTB24 ZNF124 ZNF20 ZNF417 ZNF559 ZNF581 ZNF688
Entrez ID		1589	85291
HPRD ID		01942	13944
Ensembl ID		ENSG00000231852	ENSG00000244537
Uniprot IDs		P08686 Q08AG9 Q16874	Q9BYR5
PDB IDs		2GEG 4Y8W 5VBU
Enriched GO Terms of Interacting Partners?
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