CYP21A2 and POTEB3

Data Source:
BioGRID (two hybrid)

		CYP21A2	POTEB3
Description		cytochrome P450 family 21 subfamily A member 2	POTE ankyrin domain family member B3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane
	Molecular Function	Steroid 21-monooxygenase Activity Steroid Binding Iron Ion Binding Steroid Hydroxylase Activity Heme Binding 17-hydroxyprogesterone 21-hydroxylase Activity Progesterone 21-hydroxylase Activity	Protein Binding
	Biological Process	Steroid Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Sterol Metabolic Process
Pathways		Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Ketoconazole
Diseases		Congenital adrenal hyperplasia (CAH) 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Diastolic blood pressure ( 25249183) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hypertension ( 25249183) Inflammatory bowel disease ( 28067908) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043) Prostate cancer ( 23535732) Systolic blood pressure ( 25249183) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908)
Interacting Genes		18 interacting genes: CRCT1 CREB5 CYSRT1 HOXA1 KRTAP1-3 KRTAP4-2 KRTAP9-2 LCE1F LCE2C LCE3B LCE3C LCE5A NBPF19 NOTCH2NLA NR4A3 PICK1 POTEB3 POU4F2	8 interacting genes: CYP21A2 GAS8 KRTAP4-11 KRTAP4-5 KRTAP5-9 KRTAP9-2 MACO1 PHF19
Entrez ID		1589	102724631
HPRD ID		01942
Ensembl ID		ENSG00000231852	ENSG00000278522
Uniprot IDs		P08686 Q08AG9 Q16874	A0A0C4DH93 A0JP26
PDB IDs		2GEG 4Y8W 5VBU
Enriched GO Terms of Interacting Partners?
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