CYBA and CYBB

Data Source:
HPRD (in vivo, in vitro)

		CYBA	CYBB
Description		cytochrome b-245 alpha chain	cytochrome b-245 beta chain
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Secretory Granule Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Tertiary Granule Membrane	Nuclear Envelope Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity	Voltage-gated Ion Channel Activity Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Heme Binding Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Inflammatory Response Smooth Muscle Hypertrophy Cytochrome Complex Assembly Electron Transport Chain Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Superoxide Anion Generation Neutrophil Degranulation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Defense Response Inflammatory Response Response To Nutrient Electron Transport Chain Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Ion Transmembrane Transport Response To Drug Superoxide Anion Generation Neutrophil Degranulation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Ethanol Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation WNT5:FZD7-mediated leishmania damping	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation
Drugs		Dextromethorphan	Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)
Interacting Genes		13 interacting genes: APPBP2 CPT1A CYBB MDFI NCF1 NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2	7 interacting genes: ACTG1 CYBA CYBC1 IQGAP1 NCF2 NCF4 RAC1
Entrez ID		1535	1536
HPRD ID		01989	02382
Ensembl ID		ENSG00000051523	ENSG00000165168
Uniprot IDs		B4DT46 H3BNP7 P13498	A0A0S2Z3S6 P04839
PDB IDs		1WLP	3A1F
Enriched GO Terms of Interacting Partners?
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