CYBA and CPT1A

Data Source:
BioGRID (two hybrid)

		CYBA	CPT1A
Description		cytochrome b-245 alpha chain	carnitine palmitoyltransferase 1A
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Secretory Granule Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Tertiary Granule Membrane	Mitochondrion Mitochondrial Outer Membrane Membrane Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity	Carnitine O-palmitoyltransferase Activity Identical Protein Binding Palmitoleoyltransferase Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Inflammatory Response Smooth Muscle Hypertrophy Cytochrome Complex Assembly Electron Transport Chain Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Superoxide Anion Generation Neutrophil Degranulation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process	Long-chain Fatty Acid Metabolic Process Glucose Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Triglyceride Metabolic Process Carnitine Shuttle Circadian Rhythm Carnitine Metabolic Process Regulation Of Lipid Storage Response To Organic Cyclic Compound Regulation Of Lipid Metabolic Process Epithelial Cell Differentiation Response To Nutrient Levels Positive Regulation Of Fatty Acid Beta-oxidation Response To Drug Eating Behavior Response To Alkaloid Response To Ethanol Response To Antibiotic Regulation Of Insulin Secretion Cellular Response To Fatty Acid Liver Regeneration Response To Tetrachloromethane
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation WNT5:FZD7-mediated leishmania damping	RORA activates gene expression PPARA activates gene expression Carnitine metabolism Signaling by Retinoic Acid
Drugs		Dextromethorphan	Levocarnitine Glyburide Perhexiline
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)	Apolipoprotein A1 levels ( 32203549) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) HDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 22286219) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Obesity-related traits ( 23251661) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549 32154731) Urate levels ( 31578528)
Interacting Genes		13 interacting genes: APPBP2 CPT1A CYBB MDFI NCF1 NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2	8 interacting genes: BCL2 CLIC1 CYBA HSPA5 KBTBD7 NPDC1 NR4A1 UBC
Entrez ID		1535	1374
HPRD ID		01989	02755
Ensembl ID		ENSG00000051523	ENSG00000110090
Uniprot IDs		B4DT46 H3BNP7 P13498	A0A024R5F4 B2RAQ8 P50416 Q8WZ48
PDB IDs		1WLP	2LE3
Enriched GO Terms of Interacting Partners?
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