SLC25A48 and EFEMP2

Data Source:
BioGRID (two hybrid)

		SLC25A48	EFEMP2
Description		solute carrier family 25 member 48	EGF containing fibulin extracellular matrix protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Inner Membrane Integral Component Of Membrane	Microfibril Extracellular Region Basement Membrane Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber Extracellular Vesicle
	Molecular Function	Protein Binding Acyl Carnitine Transmembrane Transporter Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Protein Homodimerization Activity
	Biological Process	Acyl Carnitine Transport Amino Acid Transport Acyl Carnitine Transmembrane Transport	Aorta Development Elastic Fiber Assembly Aorta Smooth Muscle Tissue Morphogenesis Vascular Associated Smooth Muscle Cell Development Regulation Of Collagen Fibril Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways			Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Obesity-related traits ( 23251661) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (dichotomous) ( 28628665)	Acne (severe) ( 24927181) Adult body size ( 32376654) Birth weight ( 31043758) Body size at age 10 ( 32376654) Retinal detachment or retinal break ( 31816047)
Interacting Genes		14 interacting genes: ATN1 CCDC57 CYSRT1 EFEMP2 GUCD1 KRTAP10-3 KRTAP10-7 MGAT5B MID2 MTUS2 PNMA1 RBPMS TRAF1 UBASH3B	130 interacting genes: ADAMTSL4 AMMECR1 ANAPC11 AP1M1 APEX2 AQP1 ARRDC3 ATN1 ATXN1 ATXN7 BAG6 C3 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK CDPF1 CLPP CNNM3 COL8A1 CREB5 CXCL5 CYSRT1 DGCR6 DOK7 FAM107A FAM110A FAM124B FAM74A4 FAM90A1 FBXW5 FTO GFI1B GLRX3 HDAC4 HHEX HHIPL1 HOXA1 HPCAL1 HSD3B7 HSPA12B HSPBP1 IGFBP6 IL16 INCA1 ITGB5 KLF1 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP26-1 KRTAP3-2 LBX1 LCE1A LCE1C LCE1E LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LINGO1 LNX1 MDFI MEOX2 MRPL12 MXI1 NEDD4L NOS3 NR1D2 NTM NUFIP2 OTX1 P2RX7 PIDD1 PITX1 PLSCR1 PLSCR4 PROP1 PRPF31 PRR32 PTGER3 RAB40B RBAK RBP3 RBPMS RERE RHOXF2 RHPN1 RIBC2 RNF138 SGTA SGTB SLC16A5 SLC23A1 SLC25A48 SPACA9 SPATA24 SPATA3 SPATA8 SPRY4 STK16 TCAF1 THAP7 TLE5 TLX3 TP53 TRIB3 TRIM42 UBQLN1 UBQLN4 USP21 ZNF263 ZNF345 ZNF426 ZNF558 ZNF57 ZNF581 ZNF587 ZNF638 ZNF670 ZNF699 ZNF768 ZNF774 ZNF837
Entrez ID		153328	30008
HPRD ID		14098	05221
Ensembl ID		ENSG00000145832	ENSG00000172638
Uniprot IDs		Q6ZT89	A0A024R5G1 O95967 Q9H3D5
PDB IDs			2KL7
Enriched GO Terms of Interacting Partners?
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