CCDC24 and FNTB

Data Source:
BioGRID (two hybrid)

		CCDC24	FNTB
Description		coiled-coil domain containing 24	farnesyltransferase, CAAX box, beta
Image		No pdb structure
GO Annotations	Cellular Component		Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex
	Molecular Function	Protein Binding	Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Blastocyst Hatching	Protein Phosphopantetheinylation Protein Prenylation Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway
Pathways			Inactivation, recovery and regulation of the phototransduction cascade RAS processing
Drugs			AZD3409 Tipifarnib Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Blood trace element (Zn levels) ( 23720494) Eosinophil counts ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		35 interacting genes: ADRA2C AKAP8L ANTKMT CDC23 DISC1 FAM166B FNTB GATA1 HYI IKZF3 KRT33B KRT34 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-3 LRP2BP MAGEA6 NDUFAB1 NDUFB7 OIP5 REN RNF31 TCEAL8 TRIM42 TRIP6 TTC23 TTC23L USHBP1 USP54 WWOX ZMYND12	17 interacting genes: AGXT APOL6 ATPAF2 CCDC24 CENPF FNTA GBP1 HDAC6 HOXC8 HRAS KRAS KRBA1 PTP4A3 RAP2A RRAS2 SMG9 TLX3
Entrez ID		149473	2342
HPRD ID		14636	00608
Ensembl ID		ENSG00000159214	ENSG00000257365
Uniprot IDs		Q8N4L8	A0A384MEJ5 P49356
PDB IDs			1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?
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