RFLNA and FDFT1

Data Source:
HPRD (two hybrid)

		RFLNA	FDFT1
Description		refilin A	farnesyl-diphosphate farnesyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Actin Filament Bundle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Filamin Binding	Farnesyl-diphosphate Farnesyltransferase Activity Protein Binding Metal Ion Binding Squalene Synthase Activity
	Biological Process	Skeletal System Morphogenesis Negative Regulation Of Chondrocyte Development Actin Filament Bundle Organization Negative Regulation Of Bone Mineralization Involved In Bone Maturation	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Regulation Of Lipid Metabolic Process Farnesyl Diphosphate Metabolic Process Regulation Of Cholesterol Biosynthetic Process
Pathways			Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)
Drugs			TAK-475
Diseases
GWAS		Hallux valgus ( 32131869) Optic cup area ( 31798171) Osteoarthrosis (time to event) ( 32589924) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535)	Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Platelet count ( 32888494) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		3 interacting genes: FBXW7 FDFT1 FLNA	25 interacting genes: ANXA5 AQP6 ARL13B ARL6IP1 CD74 CD79A CLN5 CREB3 ELOVL4 FAM209A GJA8 GPR152 ITGB5 JAGN1 LMNA NCAPH2 PANX1 RFLNA RUVBL2 SHPRH SLC10A1 SLC35C2 TLCD4 TMEM43 TMX2
Entrez ID		144347	2222
HPRD ID		14066	01694
Ensembl ID		ENSG00000178882	ENSG00000079459
Uniprot IDs		Q6ZTI6	A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1
PDB IDs			1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA 6PYJ 6PYV 6PYW 6PZ5
Enriched GO Terms of Interacting Partners?
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