FDFT1 and ITGB5

Data Source:
BioGRID (two hybrid)

		FDFT1	ITGB5
Description		farnesyl-diphosphate farnesyltransferase 1	integrin subunit beta 5
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Farnesyl-diphosphate Farnesyltransferase Activity Protein Binding Metal Ion Binding Squalene Synthase Activity	Virus Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Regulation Of Lipid Metabolic Process Farnesyl Diphosphate Metabolic Process Regulation Of Cholesterol Biosynthetic Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Muscle Contraction Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Extracellular Matrix Organization Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Stress Fiber Assembly Viral Entry Into Host Cell Epithelial Cell-cell Adhesion
Pathways		Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)	Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction
Drugs		TAK-475
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Platelet count ( 32888494) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Airway hyperresponsiveness ( 23984888) Carpal tunnel syndrome ( 30833571) Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin concentration ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		25 interacting genes: ANXA5 AQP6 ARL13B ARL6IP1 CD74 CD79A CLN5 CREB3 ELOVL4 FAM209A GJA8 GPR152 ITGB5 JAGN1 LMNA NCAPH2 PANX1 RFLNA RUVBL2 SHPRH SLC10A1 SLC35C2 TLCD4 TMEM43 TMX2	58 interacting genes: ANXA5 APPBP2 CCN1 CYSRT1 DAB1 DAB2 DOK1 EFEMP2 EHMT2 EPS8 EWSR1 FDFT1 FHL2 FHL3 FLNA GAPDH GOLGA2 GON4L ITGA5 ITGAV ITGB3BP KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP5-7 LTBP1 LTBP3 MTDH MTUS2 MYBPC2 MYO10 NBPF19 NOTCH2NLA NUMB P2RY2 PAK4 PALLD PPARD PTK2 RACK1 SNTA1 SPP1 SRSF9 STAB2 TAF1 TLN1 TNS2 TRIM55 TRIM63 TTN ZBTB17 ZNF655
Entrez ID		2222	3693
HPRD ID		01694	00949
Ensembl ID		ENSG00000079459	ENSG00000082781
Uniprot IDs		A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1	D3DNA1 L7RT22 P18084
PDB IDs		1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA 6PYJ 6PYV 6PYW 6PZ5
Enriched GO Terms of Interacting Partners?
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