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MAPK14 and RET
Data Source:
HPRD
(in vitro)
MAPK14
RET
Description
mitogen-activated protein kinase 14
ret proto-oncogene
Image
GO Annotations
Cellular Component
Spindle Pole
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Nuclear Speck
Secretory Granule Lumen
Glutamatergic Synapse
Ficolin-1-rich Granule Lumen
Early Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Endosome Membrane
Axon
Dendrite
Neuronal Cell Body
Receptor Complex
Membrane Raft
Plasma Membrane Protein Complex
Molecular Function
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Enzyme Binding
Protein Phosphatase Binding
Mitogen-activated Protein Kinase P38 Binding
NFAT Protein Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Signaling Receptor Activity
Biological Process
DNA Damage Checkpoint
Activation Of MAPK Activity
Cell Morphogenesis
Cartilage Condensation
Angiogenesis
Placenta Development
Chondrocyte Differentiation
Glucose Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Chemotaxis
Signal Transduction
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Ras Protein Signal Transduction
Skeletal Muscle Tissue Development
Positive Regulation Of Gene Expression
Positive Regulation Of Myotube Differentiation
Peptidyl-serine Phosphorylation
Fatty Acid Oxidation
Regulation Of Ossification
Osteoclast Differentiation
Positive Regulation Of Cyclase Activity
Lipopolysaccharide-mediated Signaling Pathway
Response To Muramyl Dipeptide
Positive Regulation Of Interleukin-12 Production
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Response To Muscle Stretch
P38MAPK Cascade
Positive Regulation Of Protein Import Into Nucleus
Signal Transduction In Response To DNA Damage
Neutrophil Degranulation
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Glucose Import
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Striated Muscle Cell Differentiation
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Cardiac Muscle Cell Proliferation
3'-UTR-mediated MRNA Stabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Tumor Necrosis Factor
Cellular Response To Ionizing Radiation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Brown Fat Cell Differentiation
Stress-induced Premature Senescence
Cellular Response To Virus
Regulation Of Synaptic Membrane Adhesion
Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Myoblast Fusion
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Reactive Oxygen Species Metabolic Process
MAPK Cascade
Activation Of MAPK Activity
Ureteric Bud Development
Neural Crest Cell Migration
Embryonic Epithelial Tube Formation
Protein Phosphorylation
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Neuron Cell-cell Adhesion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Posterior Midgut Development
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Neuron Maturation
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Migration
Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Membrane Protein Proteolysis
Positive Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Kinase Activity
Ureter Maturation
Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Response To Drug
Neuron Maturation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cell Size
Positive Regulation Of Transcription, DNA-templated
Response To Pain
Enteric Nervous System Development
Regulation Of Axonogenesis
Positive Regulation Of Protein Kinase B Signaling
Retina Development In Camera-type Eye
Innervation
Peyer's Patch Morphogenesis
Cellular Response To Retinoic Acid
Positive Regulation Of Metanephric Glomerulus Development
Lymphocyte Migration Into Lymphoid Organs
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
NOD1/2 Signaling Pathway
p38MAPK events
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Oxidative Stress Induced Senescence
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNA
Myogenesis
Myogenesis
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation
CD163 mediating an anti-inflammatory response
RAF/MAP kinase cascade
RET signaling
Drugs
Minocycline
Dasatinib
4-[5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine
N-[(3Z)-5-Tert-butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene]-N'-(4-chlorophenyl)urea
1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One
Inhibitor of P38 Kinase
6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine
3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine
1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea
3-(Benzyloxy)Pyridin-2-Amine
1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One
4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline
Doramapimod
2-Chlorophenol
4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole
SB220025
4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE
Triazolopyridine
KC706
Talmapimod
VX-702
R-1487
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide
Neflamapimod
N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide
4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE
4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE
N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide
4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE
4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide
N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide
N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide
PH-797804
2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine
SD-0006
N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA
N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO-
3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE
3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide
3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE
3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA
8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM
2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE
N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide
N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE
[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE
[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE
4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine
4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE
3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE
Fostamatinib
Sorafenib
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Vandetanib
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Fostamatinib
Amuvatinib
Selpercatinib
Pralsetinib
Diseases
Hirschsprung disease (HD)
Renal agenesis and Renal adysplasia
Thyroid cancer
Congenital central hypoventilation syndrome (CCHS)
GWAS
Foot ulcer in diabetes and neuropathy (
28672053
)
Blood protein levels (
30072576
29875488
28240269
)
Cannabis dependence symptom count (
27028160
)
Hirschsprung disease (
19196962
30031151
25310821
29379196
27702942
)
Smoking behaviour (cigarettes smoked per day) (
31089300
)
Interacting Genes
165 interacting genes:
AIMP1
AKT1
ARNT
ATF2
BCL2
BCL2L1
BICD1
BMI1
CCDC14
CCDC97
CCND2
CD4
CDC25A
CDC25B
CDC25C
CDK4
CDK6
CDKN2A
CDT1
CDX2
CENPC
CEP164
COPS5
CREB1
CSNK2A1
CSNK2A2
CSNK2B
DAB1
DDIT3
DUSP1
DUSP10
DUSP16
DUSP2
DUSP22
DUSP4
DUSP7
DUSP9
DYRK1B
EEA1
EEF1A1
EEF2K
EGFR
EIF4EBP1
ELK1
ELK3
EPB42
EPHA2
EPS15
ESR1
ETV1
FGFR4
FKBP8
FLNA
GADD45A
GATA3
GDF15
GMFB
GORASP2
GRB2
HDAC3
HIVEP1
HNF4A
HSF4
HSPB1
HTRA2
ILKAP
INTS6L
IRAK1
JDP2
JUN
JUNB
KAT2A
KAT2B
KMT2C
KRT18
KRT8
LATS2
LIMK1
MAFA
MAP2K1
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAP3K10
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MAPKAPK3
MAPKAPK5
MAPT
MARS1
MAX
MBP
MEF2A
MEF2C
MEF2D
MIDEAS
MITF
MKNK1
MKNK2
MOB3B
MUC12
MYC
NCOA3
NF2
NFATC1
NFATC4
NFIC
NKTR
NRL
NUP153
PAK6
PHC2
PI4K2B
PLA2G4A
PLG
PML
PPARGC1A
PPP4R3A
PTPN7
RB1
RBSN
RELA
RET
ROBO1
RPL22
RPL41
RPS6KA4
RPS6KA5
S100A9
SCN8A
SH2D1A
SHC1
SLC9A1
SMAD3
SMAD7
SMARCD3
SNAPIN
SPAG9
SPTBN1
SQSTM1
SRPK1
SRSF5
STAT1
STAT4
STK11
STK39
SUPT20H
TAB1
TCF20
TFCP2
TLE5
TMEM63B
TP53
TRAF6
TSC1
UGT2B10
ULK1
YY1AP1
ZFP36L1
ZNF142
ZNHIT1
44 interacting genes:
AKAP5
CBL
CBLB
CRK
DOK1
DOK2
DOK3
DOK4
DOK5
DOK6
DUSP26
ERBB2
FBXO7
FRS2
GAB1
GDNF
GFRA1
GRB10
GRB2
GRB7
IKBKG
LRRK1
MAPK1
MAPK14
MAPK3
MAPK8
NEDD4
NOTCH2NLA
NOTCH3
NRTN
PDLIM7
PIK3R1
PLCG1
PRKAR2A
PTK2
PTPN11
PTPRA
PTPRF
PTPRR
SHC1
SHC3
SHC4
SRC
STAT3
Entrez ID
1432
5979
HPRD ID
02619
01266
Ensembl ID
ENSG00000112062
ENSG00000165731
Uniprot IDs
A0A024RD15
B4E0K5
L7RSM2
Q16539
A0A024R7T2
P07949
PDB IDs
1A9U
1BL6
1BL7
1BMK
1DI9
1IAN
1KV1
1KV2
1M7Q
1OUK
1OUY
1OVE
1OZ1
1R39
1R3C
1W7H
1W82
1W83
1W84
1WBN
1WBO
1WBS
1WBT
1WBV
1WBW
1WFC
1YQJ
1ZYJ
1ZZ2
1ZZL
2BAJ
2BAK
2BAL
2BAQ
2FSL
2FSM
2FSO
2FST
2GFS
2I0H
2LGC
2NPQ
2OKR
2ONL
2QD9
2RG5
2RG6
2Y8O
2YIS
2YIW
2YIX
2ZAZ
2ZB0
2ZB1
3BV2
3BV3
3BX5
3C5U
3CTQ
3D7Z
3D83
3DS6
3DT1
3E92
3E93
3FC1
3FI4
3FKL
3FKN
3FKO
3FL4
3FLN
3FLQ
3FLS
3FLW
3FLY
3FLZ
3FMH
3FMJ
3FMK
3FML
3FMM
3FMN
3FSF
3FSK
3GC7
3GCP
3GCQ
3GCS
3GCU
3GCV
3GFE
3GI3
3HA8
3HEC
3HEG
3HL7
3HLL
3HP2
3HP5
3HRB
3HUB
3HUC
3HV3
3HV4
3HV5
3HV6
3HV7
3HVC
3IPH
3ITZ
3IW5
3IW6
3IW7
3IW8
3K3I
3K3J
3KF7
3KQ7
3L8S
3L8X
3LFA
3LFB
3LFC
3LFD
3LFE
3LFF
3LHJ
3MGY
3MH0
3MH1
3MH2
3MH3
3MPA
3MPT
3MVL
3MVM
3MW1
3NEW
3NNU
3NNV
3NNW
3NNX
3NWW
3O8P
3O8T
3O8U
3OBG
3OBJ
3OC1
3OCG
3OD6
3ODY
3ODZ
3OEF
3PG3
3QUD
3QUE
3RIN
3ROC
3S3I
3S4Q
3U8W
3UVP
3UVQ
3UVR
3ZS5
3ZSG
3ZSH
3ZSI
3ZYA
4A9Y
4AA0
4AA4
4AA5
4AAC
4DLI
4DLJ
4E5A
4E5B
4E6A
4E6C
4E8A
4EH2
4EH3
4EH4
4EH5
4EH6
4EH7
4EH8
4EH9
4EHV
4EWQ
4F9W
4F9Y
4FA2
4GEO
4KIN
4KIP
4KIQ
4L8M
4R3C
4ZTH
5ETA
5ETC
5ETF
5ETI
5ML5
5MTX
5MTY
5MZ3
5N63
5N64
5N65
5N66
5N67
5N68
5O8U
5O8V
5OMG
5OMH
5TBE
5TCO
5WJJ
5XYX
5XYY
6ANL
6HWT
6HWU
6HWV
6M95
6M9L
6OHD
6QDZ
6QE1
6QYX
6RFO
6SFI
6SFJ
6SFK
6SFO
6TCA
6ZWP
1XPD
2IVS
2IVT
2IVU
2IVV
2X2K
2X2L
2X2M
2X2U
4CKI
4CKJ
4UX8
5AMN
5FM2
5FM3
6FEK
6GL7
6I82
6I83
6NE7
6NEC
6NJA
6Q2J
6Q2N
6Q2O
6Q2R
6Q2S
6VHG
Enriched GO Terms of Interacting Partners
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