RET and DOK5

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		RET	DOK5
Description		ret proto-oncogene	docking protein 5
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GO Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Membrane Raft Plasma Membrane Protein Complex	Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Signaling Receptor Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Response To Drug Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Protein Kinase B Signaling Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Positive Regulation Of MAPK Cascade Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Pathways		RAF/MAP kinase cascade RET signaling	RET signaling
Drugs		Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib
Diseases		Hirschsprung disease (HD) Renal agenesis and Renal adysplasia Thyroid cancer Congenital central hypoventilation syndrome (CCHS)
GWAS		Blood protein levels ( 30072576 29875488 28240269) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 30031151 25310821 29379196 27702942) Smoking behaviour (cigarettes smoked per day) ( 31089300)	Celiac disease ( 23936387) Erectile dysfunction ( 30583798) Functional MRI ( 20215924)
Interacting Genes		44 interacting genes: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRA PTPRF PTPRR SHC1 SHC3 SHC4 SRC STAT3	20 interacting genes: AHDC1 ATF3 BNIP3L CCDC85B CDCA4 DOK3 EGFR FANCG IGF1R INSR NTRK2 NTRK3 OLIG1 OPRM1 PFDN5 RAI2 RET SCOC TSC1 WIZ
Entrez ID		5979	55816
HPRD ID		01266	16317
Ensembl ID		ENSG00000165731	ENSG00000101134
Uniprot IDs		A0A024R7T2 P07949	Q9P104
PDB IDs		1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6I82 6I83 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S 6VHG	1J0W
Enriched GO Terms of Interacting Partners?
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