DUSP19 and ALK

Data Source:
BioGRID (two hybrid)

		DUSP19	ALK
Description		dual specificity phosphatase 19	ALK receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Extracellular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Phosphatase Activity Protein Kinase Activator Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Peptidyl-tyrosine Dephosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade	Activation Of MAPK Activity Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Phosphorylation Peptidyl-tyrosine Phosphorylation Hippocampus Development Adult Behavior Positive Regulation Of Kinase Activity Swimming Behavior NIK/NF-kappaB Signaling Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development
Pathways
Drugs			ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases			Non-small cell lung cancer
GWAS			Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751)
Interacting Genes		20 interacting genes: ACTB ALAS1 ALK EGFR EPHA2 EPHB6 ERBB2 ERBB3 ERBB4 FLT4 IGF1R INSR KDR LMTK2 MAP2K7 MAP3K5 MAPK9 PTK7 ROR1 ROR2	16 interacting genes: DUSP19 ERBB2 IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PPM1A PTN PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1
Entrez ID		142679	238
HPRD ID		13254	00104
Ensembl ID		ENSG00000162999	ENSG00000171094
Uniprot IDs		Q8WTR2	B6D4Y2 Q9UM73
PDB IDs		3S4E 4D3P 4D3Q 4D3R	2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8
Enriched GO Terms of Interacting Partners?
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