ALK and ZC3HC1

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		ALK	ZC3HC1
Description		ALK receptor tyrosine kinase	zinc finger C3HC-type containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Extracellular Exosome	Nucleus Nucleoplasm Nuclear Membrane
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Binding Zinc Ion Binding Protein Kinase Binding
	Biological Process	Activation Of MAPK Activity Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Phosphorylation Peptidyl-tyrosine Phosphorylation Hippocampus Development Adult Behavior Positive Regulation Of Kinase Activity Swimming Behavior NIK/NF-kappaB Signaling Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development	Cell Cycle Protein Ubiquitination Cell Division Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs		ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases		Non-small cell lung cancer
GWAS		Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751)	Coronary artery disease ( 32469254 29212778 24262325 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878 27618452) Eosinophil counts ( 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Myocardial infarction ( 26343387) Neutrophil count ( 32888494) Parental lifespan ( 30642433) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494) Systolic blood pressure ( 27841878 28739976 27618452) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		16 interacting genes: DUSP19 ERBB2 IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PPM1A PTN PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1	11 interacting genes: ALK APP CUL1 MAPK1 MAPK3 PDPK1 TNFSF11 TRIM55 TRIM63 TSC22D1 YWHAE
Entrez ID		238	51530
HPRD ID		00104	11390
Ensembl ID		ENSG00000171094	ENSG00000091732
Uniprot IDs		B6D4Y2 Q9UM73	Q86WB0
PDB IDs		2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8
Enriched GO Terms of Interacting Partners?
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