CRYBA1 and CERK

Data Source:
BioGRID (two hybrid)

		CRYBA1	CERK
Description		crystallin beta A1	ceramide kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function Structural Constituent Of Eye Lens Protein Binding	Magnesium Ion Binding Lipid Kinase Activity Ceramide Kinase Activity NAD+ Kinase Activity Protein Binding ATP Binding Dihydroceramide Kinase Activity
	Biological Process	Negative Regulation Of Cytokine Production Lens Development In Camera-type Eye Visual Perception Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Anoikis	Sphingolipid Metabolic Process Ceramide Metabolic Process Glycosphingolipid Metabolic Process Phosphorylation Lipid Phosphorylation
Pathways			Glycosphingolipid metabolism
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Mean reticulocyte volume ( 32888494) Night sleep phenotypes ( 27126917)	Aseptic loosening in total joint arthroplasty ( 31791832) Triglyceride levels ( 30108155)
Interacting Genes		24 interacting genes: ARID5A BANF2 CELF6 CERK CHCHD2 CRYAA CRYAB CRYBB1 CRYBB2 CRYBB3 CYSRT1 FOXH1 HOXC8 KRTAP11-1 KRTAP13-2 KRTAP13-3 LASP1 NOXA1 PLEKHF2 PROP1 RBPMS RHOXF2 VAC14 YPEL3	21 interacting genes: ALAS1 APP CRYBA1 CYSRT1 KRT34 KRTAP1-1 KRTAP10-3 KRTAP11-1 KRTAP19-1 KRTAP19-6 KRTAP3-1 KRTAP3-2 KRTAP6-2 KRTAP9-2 MTUS2 NBPF19 NHLRC4 NOTCH2NLA OIP5 PLEKHF2 TRIM42
Entrez ID		1411	64781
HPRD ID		00429	09878
Ensembl ID		ENSG00000108255	ENSG00000100422
Uniprot IDs		P05813	A0A024R4U8 Q8TCT0
PDB IDs
Enriched GO Terms of Interacting Partners?
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