SREK1 and SNRPD1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SREK1	SNRPD1
Description		splicing regulatory glutamic acid and lysine rich protein 1	small nuclear ribonucleoprotein D1 polypeptide
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Nuclear Speck	Commitment Complex Nucleus Nucleoplasm U5 SnRNP U1 SnRNP U2 SnRNP U4 SnRNP U12-type Spliceosomal Complex Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex
	Molecular Function	RNA Binding Protein Binding	RNA Binding Protein Binding U1 SnRNP Binding
	Biological Process	MRNA Processing RNA Splicing	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome RNA Splicing Import Into Nucleus
Pathways			snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		60 interacting genes: ARL6IP4 CD8A CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 NCL NPM1 PABPC1 PABPC4 PARP1 PIN1 PRPF40A RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2	18 interacting genes: CLNS1A DDX20 ERCC6 GEMIN2 GEMIN4 GEMIN5 IL7R LSM3 LSM8 PRMT5 PTEN SMN1 SMN2 SNRPB SNRPD2 SREK1 U2AF1 WDR77
Entrez ID		140890	6632
HPRD ID		18043	03040
Ensembl ID		ENSG00000153914	ENSG00000167088
Uniprot IDs		Q8WXA9	P62314
PDB IDs			1B34 3CW1 3JCR 3PGW 4F7U 4PJO 4V98 4WZJ 5MQF 5O9Z 5XJC 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6Y53 6Y5Q 7A5P
Enriched GO Terms of Interacting Partners?
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