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CRY2 and PER2
Data Source:
BioGRID
(two hybrid, affinity chromatography technology, two hybrid)
HPRD
(in vivo)
CRY2
PER2
Description
cryptochrome circadian regulator 2
period circadian regulator 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Cytosol
Nuclear Speck
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Perinuclear Region Of Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Deoxyribodipyrimidine Photo-lyase Activity
DNA (6-4) Photolyase Activity
Protein Binding
Blue Light Photoreceptor Activity
Phosphatase Binding
FAD Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Transcription Corepressor Binding
Transcription Coactivator Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Photoreactive Repair
Circadian Rhythm
Response To Light Stimulus
Blue Light Signaling Pathway
Response To Activity
Protein-chromophore Linkage
Negative Regulation Of Phosphoprotein Phosphatase Activity
Circadian Regulation Of Gene Expression
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Transcription, DNA-templated
Regulation Of Sodium-dependent Phosphate Transport
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Response To Ischemia
Glycogen Biosynthetic Process
Gluconeogenesis
Fatty Acid Metabolic Process
Circadian Rhythm
Regulation Of Vasoconstriction
Lactate Biosynthetic Process
Negative Regulation Of Protein Ubiquitination
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Negative Regulation Of Circadian Rhythm
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Regulation Of Neurogenesis
Regulation Of Insulin Secretion
White Fat Cell Differentiation
Regulation Of Cell Cycle
Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse
Negative Regulation Of Fat Cell Proliferation
Histone H3 Deacetylation
Circadian Regulation Of Translation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways
Circadian Clock
Circadian Clock
Drugs
Diseases
Familial advanced sleep phase syndrome
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Axial length (
24144296
)
Fasting blood glucose (
20081858
22581228
)
Fasting blood glucose (BMI interaction) (
22581228
)
Glycemic traits (pleiotropy) (
31021400
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
30297969
)
Visceral fat (
22589738
)
Chronotype (
26955885
30696823
27494321
)
Morning vs. evening chronotype (
26955885
26835600
27494321
)
Interacting Genes
50 interacting genes:
ATXN1
BHLHE41
BRCA1
CLOCK
CTBP1
CYSRT1
DELEC1
EZH2
KLHL6
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP19-6
KRTAP4-2
KRTAP5-1
KRTAP5-2
KRTAP5-4
KRTAP5-7
KRTAP5-9
KRTAP6-3
KRTAP9-8
LMNA
MID1
MTUS2
NADK
NBPF19
NOTCH2NLA
NPAS2
PDE9A
PER1
PER2
PER3
PICK1
PPP2R1B
PPP2R5D
PPP2R5E
PPP5C
PTGER4
SBK3
SDCBP2
STK11
TIMELESS
TRAF1
TRAF2
TTC1
VWC2
XRN2
ZBTB42
25 interacting genes:
BHLHE41
BTRC
CLOCK
CRY1
CRY2
CSNK1D
CSNK1E
CSNK2B
DELEC1
ELOA
LENG8
LMO4
MDM2
MLH1
PER1
PER3
RORC
TIMELESS
TP53
TPT1
TPTEP2-CSNK1E
UBE2D1
UBE2D2
UBE2D3
UBL4A
Entrez ID
1408
8864
HPRD ID
07226
04575
Ensembl ID
ENSG00000121671
ENSG00000132326
Uniprot IDs
A0A0D2X7Z3
A2I2P1
Q49AN0
O15055
PDB IDs
6OF7
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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