CRY2 and NADK

Data Source:
BioGRID (two hybrid)

		CRY2	NADK
Description		cryptochrome circadian regulator 2	NAD kinase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Nuclear Speck	Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding FAD Binding	NAD+ Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	NADP Biosynthetic Process Phosphorylation NAD Metabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus ATP Metabolic Process
Pathways		Circadian Clock	Nicotinate metabolism
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)	Blood protein levels ( 30072576) Body mass index ( 26426971 28892062) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Multiple sclerosis ( 31604244) Pulse pressure ( 28135244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 28135244 30578418)
Interacting Genes		50 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 CYSRT1 DELEC1 EZH2 KLHL6 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP19-6 KRTAP4-2 KRTAP5-1 KRTAP5-2 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-8 LMNA MID1 MTUS2 NADK NBPF19 NOTCH2NLA NPAS2 PDE9A PER1 PER2 PER3 PICK1 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGER4 SBK3 SDCBP2 STK11 TIMELESS TRAF1 TRAF2 TTC1 VWC2 XRN2 ZBTB42	10 interacting genes: CRY2 EEF1G FAM124B GLRX3 GRB2 LNX1 NUDT18 SDCBP SRPK2 YWHAQ
Entrez ID		1408	65220
HPRD ID		07226	16907
Ensembl ID		ENSG00000121671	ENSG00000008130
Uniprot IDs		A0A0D2X7Z3 A2I2P1 Q49AN0	A0A024R058 A0A0A0MR98 O95544 Q6PJ22
PDB IDs			3PFN
Enriched GO Terms of Interacting Partners?
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