RIMS4 and PELI1

Data Source:
BioGRID (two hybrid)

		RIMS4	PELI1
Description		regulating synaptic membrane exocytosis 4	pellino E3 ubiquitin protein ligase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Presynaptic Active Zone Synaptic Membrane	Condensed Nuclear Chromosome Kinetochore Cytosol
	Molecular Function	Protein Binding Ion Channel Binding	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Neurotransmitter Transport Exocytosis Regulation Of Membrane Potential Regulation Of Synaptic Vesicle Exocytosis	Protein Polyubiquitination Positive Regulation Of Cytokine Production Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To DsRNA Negative Regulation Of Necroptotic Process Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways			Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Meat-related diet ( 32066663) Obesity-related traits ( 23251661)	Allergic dermatitis (nickel) ( 23921680) HOMA-B (corrected for HOMA-IR) ( 30369944) Kawasaki disease ( 21221998)
Interacting Genes		4 interacting genes: APP PELI1 SPP1 SRPK1	31 interacting genes: BCL6 BIRC3 BUB1B CLEC17A CNTROB GOSR2 IKBKB INPP5J IRAK1 IRAK2 IRAK4 IRS1 LCN2 LMNA MDM4 RIMS4 RIPK1 RIPK3 SRPK1 SRPK2 TP53 TP63 TRIP13 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2V1 VAC14
Entrez ID		140730	57162
HPRD ID		17977	17834
Ensembl ID		ENSG00000101098	ENSG00000197329
Uniprot IDs		Q9H426	Q53T26 Q96FA3
PDB IDs
Enriched GO Terms of Interacting Partners?
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