CPB2 and PZP

Data Source:
HPRD (in vitro)

		CPB2	PZP
Description		carboxypeptidase B2	PZP alpha-2-macroglobulin like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Positive Regulation Of Extracellular Matrix Constituent Secretion Proteolysis Blood Coagulation Response To Heat Negative Regulation Of Plasminogen Activation Regulation Of Complement Activation Response To Drug Fibrinolysis Negative Regulation Of Fibrinolysis Cellular Response To Glucose Stimulus Liver Regeneration Negative Regulation Of Hepatocyte Proliferation	Female Pregnancy Negative Regulation Of Endopeptidase Activity
Pathways		Metabolism of Angiotensinogen to Angiotensins Regulation of Complement cascade
Drugs		AZD-9684 Prothrombin
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)	Blood protein levels ( 29875488) Depression in smokers ( 30219690) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Low density lipoprotein cholesterol levels ( 32154731) Myopia ( 27182965) Non-alcoholic fatty liver disease histology (AST) ( 20708005) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		6 interacting genes: A2M C5 F2 PLG PZP TINAG	6 interacting genes: CPB2 KLK3 MMP2 MMP9 TGFB1 TGFB2
Entrez ID		1361	5858
HPRD ID		04374	07178
Ensembl ID		ENSG00000080618	ENSG00000126838
Uniprot IDs		A0A087WSY5 Q96IY4
PDB IDs		3D66 3D67 3D68 3LMS 4P10 5HVF 5HVG 5HVH
Enriched GO Terms of Interacting Partners?
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