PZP and KLK3

Data Source:
HPRD (in vitro)

		PZP	KLK3
Description		PZP alpha-2-macroglobulin like	kallikrein related peptidase 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nucleus Secretory Granule Protein-containing Complex Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
	Biological Process	Female Pregnancy Negative Regulation Of Endopeptidase Activity	Antibacterial Peptide Production Regulation Of Systemic Arterial Blood Pressure Proteolysis Negative Regulation Of Angiogenesis Zymogen Activation Cellular Protein Metabolic Process
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs			Mifepristone Cyproterone acetate Gallium Ga-68 gozetotide
Diseases
GWAS		Blood protein levels ( 29875488) Depression in smokers ( 30219690) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Low density lipoprotein cholesterol levels ( 32154731) Myopia ( 27182965) Non-alcoholic fatty liver disease histology (AST) ( 20708005) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Celiac disease ( 23936387) Elevated serum prostate-specific antigen levels in healthy men ( 28471803) PCA3 expression level ( 23555189) Prostate cancer ( 18264097 31562322 26034056 24753544) Prostate cancer (early onset) ( 24740154) Prostate cancer aggressiveness ( 25939597) Prostate-specific antigen levels ( 25434496 23269536 28139693 24919509) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077)
Interacting Genes		6 interacting genes: CPB2 KLK3 MMP2 MMP9 TGFB1 TGFB2	14 interacting genes: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI
Entrez ID		5858	354
HPRD ID		07178	01461
Ensembl ID		ENSG00000126838	ENSG00000142515
Uniprot IDs			P07288 Q546G3
PDB IDs			1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM
Enriched GO Terms of Interacting Partners?
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