LTF and CEL

Data Source:
HPRD (in vitro)

		LTF	CEL
Description		lactotransferrin	carboxyl ester lipase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Early Endosome Plasma Membrane Cell Surface Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Recycling Endosome Extracellular Exosome Phagocytic Vesicle Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Integral Component Of Plasma Membrane Cell Surface Synapse Extracellular Exosome Presynapse
	Molecular Function	Lipopolysaccharide Binding DNA Binding Serine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Iron Ion Binding Protein Binding Heparin Binding Protein Serine/threonine Kinase Activator Activity	Catalytic Activity Sterol Esterase Activity Triglyceride Lipase Activity Protein Binding Acetylesterase Activity Heparin Binding Hydrolase Activity Signaling Receptor Activity Neurexin Family Protein Binding
	Biological Process	Ossification Regulation Of Cytokine Production Retina Homeostasis Innate Immune Response In Mucosa Proteolysis Iron Ion Transport Humoral Immune Response Antimicrobial Humoral Response Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Other Organism Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of ATPase Activity Siderophore-dependent Iron Import Into Cell Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Cellular Protein Metabolic Process Negative Regulation By Host Of Viral Process Negative Regulation Of Viral Genome Replication Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Viral Process Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Disruption In Other Organism Bone Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development	Lipid Metabolic Process Cholesterol Catabolic Process Neuron Cell-cell Adhesion Chemical Synaptic Transmission Fatty Acid Catabolic Process Protein Esterification Pancreatic Juice Secretion Intestinal Cholesterol Absorption Lipid Digestion Intestinal Lipid Catabolic Process Ceramide Catabolic Process Synaptic Vesicle Endocytosis Modulation Of Chemical Synaptic Transmission Postsynaptic Membrane Assembly Presynaptic Membrane Assembly
Pathways		Mtb iron assimilation by chelation Neutrophil degranulation Metal sequestration by antimicrobial proteins Antimicrobial peptides Amyloid fiber formation
Drugs		3h-Indole-5,6-Diol Lauric acid Nitrilotriacetic acid alpha-D-Fucopyranose Nimesulide (R)-Atenolol Parecoxib
Diseases			Maturity onset diabetes of the young (MODY)
GWAS		AIDS progression ( 21502085) Blood protein levels ( 29875488 28240269) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Inflammatory bowel disease ( 26192919) Macular thickness ( 30535121) Ulcerative colitis ( 26192919)	Blood protein levels ( 30072576 29875488) Early-onset Parkinson's disease ( 28256260)
Interacting Genes		11 interacting genes: CALM1 CD14 CEL CP EPPIN ITLN1 LCN1 LRP1 LYZ MUC7 UBC	3 interacting genes: BPGM LTF OLR1
Entrez ID		4057	1056
HPRD ID		01028	07509
Ensembl ID		ENSG00000012223	ENSG00000170835
Uniprot IDs		B3KSL2 E7ER44 P02788 Q2TUW9 V9HWI4	B4DSX9 O75612 Q86SR3 X6R868
PDB IDs		1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS
Enriched GO Terms of Interacting Partners?
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