ZNF474 and PFKFB1

Data Source:
BioGRID (two hybrid)

		ZNF474	PFKFB1
Description		zinc finger protein 474	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	Protein Binding Metal Ion Binding	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Binding Identical Protein Binding Fructose-6-phosphate Binding
	Biological Process		Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Dephosphorylation Animal Organ Regeneration Response To Insulin Positive Regulation Of Glucokinase Activity Response To Glucagon Response To Starvation Negative Regulation Of Glycolytic Process Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation Response To Glucocorticoid Response To CAMP
Pathways			PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs			D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Intraocular pressure ( 29617998)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		29 interacting genes: ABI2 ATP6V0D2 BANP C2CD6 CABP5 CCDC57 COMMD8 CPNE7 CTNNA3 FRMD8 GPATCH11 GRB2 GYS1 IL16 KCTD7 MCMBP MLH1 NOXA1 PFKFB1 PPL PRKAB2 RSPH14 SEPHS1 TCF19 TEKT4 TRIM23 TSR2 UBASH3A ZIC1	15 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PFKFB4 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688
Entrez ID		133923	5207
HPRD ID		13411	02411
Ensembl ID		ENSG00000164185	ENSG00000158571
Uniprot IDs		Q6S9Z5	I1Z9G4 P16118
PDB IDs			1K6M
Enriched GO Terms of Interacting Partners?
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