COMP and ATOX1

Data Source:
BioGRID (two hybrid)

		COMP	ATOX1
Description		cartilage oligomeric matrix protein	antioxidant 1 copper chaperone
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Cytosol
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding
	Biological Process	Skeletal System Development Chondrocyte Development Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Protein Secretion Animal Organ Morphogenesis Multicellular Organism Aging Animal Organ Senescence Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Muscle Fiber Development Artery Morphogenesis Musculoskeletal Movement Neuromuscular Process Limb Development Platelet Aggregation Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation	Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress
Pathways		Integrin cell surface interactions ECM proteoglycans	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface
Drugs		Calcium	Cisplatin Sucrose Benzamidine
Diseases		Pseudoachondroplasia (PSACH) Multiple epiphyseal dysplasia (MED)
GWAS		Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)	Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Red cell distribution width ( 32888494) Systolic blood pressure change trajectories ( 27980656)
Interacting Genes		10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB	8 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1
Entrez ID		1311	475
HPRD ID		02632	03779
Ensembl ID		ENSG00000105664	ENSG00000177556
Uniprot IDs		P49747	O00244
PDB IDs		3FBY	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L
Enriched GO Terms of Interacting Partners?
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