ATOX1 and FKBP4

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ATOX1	FKBP4
Description		antioxidant 1 copper chaperone	FKBP prolyl isomerase 4
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GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Mitochondrion Cytosol Microtubule Protein-containing Complex Neuronal Cell Body Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Copper-dependent Protein Binding Tau Protein Binding
	Biological Process	Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress	Protein Peptidyl-prolyl Isomerization Protein Folding Copper Ion Transport Negative Regulation Of Neuron Projection Development Negative Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Chaperone-mediated Protein Folding Regulation Of Cellular Response To Heat
Pathways		Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface	HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
Drugs		Cisplatin Sucrose Benzamidine
Diseases
GWAS		Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Red cell distribution width ( 32888494) Systolic blood pressure change trajectories ( 27980656)	Apolipoprotein A1 levels ( 32203549) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Quantitative traits ( 19197348)
Interacting Genes		8 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1	26 interacting genes: ACVR1 AHSA1 ATOX1 CALM1 CSNK2A1 EGFR ESR1 FES FKBP1A GLMN HSF1 HSP90AA1 HSPA4 IRF4 NR3C1 NR3C2 PHYH PTPN2 S100A1 S100A2 S100A6 SH3BP4 SMURF2 SNCA SQSTM1 STIP1
Entrez ID		475	2288
HPRD ID		03779	11794
Ensembl ID		ENSG00000177556	ENSG00000004478
Uniprot IDs		O00244	Q02790
PDB IDs		1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L	1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY 4TW8 6RCY
Enriched GO Terms of Interacting Partners?
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