ACVR1C and INHBB

Data Source:
HPRD (in vitro)

		ACVR1C	INHBB
Description		activin A receptor type 1C	inhibin subunit beta B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Activin Receptor Activity, Type I Growth Factor Binding Nodal Binding Metal Ion Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding
	Biological Process	Trophectodermal Cell Proliferation Response To Dietary Excess Protein Phosphorylation Nervous System Development Response To Glucose Lipid Storage Cell Differentiation Apoptotic Nuclear Changes Response To Insulin Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Insulin Secretion Cellular Response To Growth Factor Stimulus Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation	Ovarian Follicle Development Defense Response Cellular Response To Starvation Response To Wounding Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Production Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Cellular Response To Leptin Stimulus Adhesion Of Symbiont To Host Cell Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Oocyte Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin	Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Diastolic blood pressure ( 30224653) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Low density lipoprotein cholesterol levels ( 32154731) Offspring birth weight ( 31043758) Reticulocyte count ( 32888494) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Age-related macular degeneration ( 23326517) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 22747683 27182965) Obesity ( 21552555) Urate levels ( 31985003 23263486)
Interacting Genes		2 interacting genes: INHBB TDGF1	12 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B BMPR2 FNTA IGSF1 INHA INHBA INHBC TDGF1
Entrez ID		130399	3625
HPRD ID		10608	00934
Ensembl ID		ENSG00000123612	ENSG00000163083
Uniprot IDs		Q8NER5	P09529
PDB IDs
Enriched GO Terms of Interacting Partners?
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