REG3G and POLE4

Data Source:
BioGRID (biochemical)

		REG3G	POLE4
Description		regenerating family member 3 gamma	DNA polymerase epsilon 4, accessory subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex
	Molecular Function	Signaling Receptor Activity Peptidoglycan Binding Oligosaccharide Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Acute-phase Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Keratinocyte Proliferation Antimicrobial Humoral Response Response To Peptide Hormone Cell Wall Disruption In Other Organism Negative Regulation Of Keratinocyte Differentiation Defense Response To Gram-positive Bacterium Cytolysis By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Wound Healing	G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		Antimicrobial peptides	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Acute insulin response ( 28490609) Blood protein levels ( 30072576) Body mass index ( 26426971) Contrast sensitivity ( 24152035) Metabolite levels ( 31628463)
Interacting Genes			7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A
Entrez ID		130120	56655
HPRD ID		10137	16238
Ensembl ID		ENSG00000143954	ENSG00000115350
Uniprot IDs		Q6UW15	Q9NR33
PDB IDs
Enriched GO Terms of Interacting Partners?
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