BBS5 and COTL1

Data Source:
BioGRID (affinity chromatography technology)

		BBS5	COTL1
Description		Bardet-Biedl syndrome 5	coactosin like F-actin binding protein 1
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GO Annotations	Cellular Component	Cytosol Axoneme Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane	Extracellular Region Nucleus Cytosol Actin Filament Plasma Membrane Cortical Actin Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding Phosphatidylinositol-3-phosphate Binding	Actin Binding Protein Binding Enzyme Binding Actin Filament Binding
	Biological Process	Heart Looping Visual Perception Protein Transport Melanosome Transport Motile Cilium Assembly Intracellular Transport Response To Stimulus Cilium Assembly	Biological_process Regulation Of Actin Filament Polymerization Neutrophil Degranulation Defense Response To Fungus
Pathways		BBSome-mediated cargo-targeting to cilium	Neutrophil degranulation
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Iris heterochromicity ( 30895295)	Carotid intima media thickness x smoking interaction ( 32117412) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Cocaine dependence ( 31212010) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Heel bone mineral density ( 30598549) Macular thickness ( 30535121)
Interacting Genes		2 interacting genes: CRADD KLC3	6 interacting genes: ACTA1 ACTB ACTG1 ALOX5 PDE6H TERF2IP
Entrez ID		129880	23406
HPRD ID		10353	09482
Ensembl ID		ENSG00000163093	ENSG00000103187
Uniprot IDs		A0A0S2Z626 Q8N3I7	A0A384MTY2 Q14019
PDB IDs		6XTB	1T2L 1T3X 1T3Y 1TMW 1VFQ 1WNJ
Enriched GO Terms of Interacting Partners?
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