BBS5 and CTSK

Data Source:
BioGRID (proximity labelling technology)

		BBS5	CTSK
Description		Bardet-Biedl syndrome 5	cathepsin K
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GO Annotations	Cellular Component	Cytosol Axoneme Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane	Extracellular Region Extracellular Space Nucleoplasm Lysosome Apical Plasma Membrane Endolysosome Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding Phosphatidylinositol-3-phosphate Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process	Heart Looping Visual Perception Protein Transport Melanosome Transport Motile Cilium Assembly Intracellular Transport Response To Stimulus Cilium Assembly	Autophagy Of Mitochondrion Toll-like Receptor Signaling Pathway Proteolysis Thyroid Hormone Generation Immune Response Extracellular Matrix Disassembly Collagen Catabolic Process Regulation Of Keratinocyte Differentiation Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		BBSome-mediated cargo-targeting to cilium	Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs			[1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]Pentylcarbamate Cyanamide 3-amino-5-phenylpentane N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamide N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamide N-[(2S)-4-Methyl-1-oxo-1-{[(4S)-3-oxo-1-(2-pyridinylsulfonyl)-4-azepanyl]amino}-2-pentanyl]-1-benzofuran-2-carboxamide Dibenzyl (carbonylbis{2,1-hydrazinediyl[(2S)-4-methyl-1-oxo-1,2-pentanediyl]})biscarbamate N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide (2R)-2-(3-Biphenylyl)-N-{(2R)-2-hydroxy-3-[(2-pyridinylsulfonyl)amino]propyl}-4-methylpentanamide Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate MIV-701 Relacatib Odanacatib 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine (2R)-3-Methyl-1-phenyl-2-butanyl [(2S)-1-oxo-2-hexanyl]carbamate 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE (1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamide TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE MIV-711
Diseases		Bardet-Biedl syndrome (BBS)	Pycnodysostosis
GWAS		Iris heterochromicity ( 30895295)	Blood protein levels ( 28240269) Body mass index ( 26426971) Congenital left-sided heart lesions ( 26965164) Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		2 interacting genes: CRADD KLC3	6 interacting genes: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC
Entrez ID		129880	1513
HPRD ID		10353	03064
Ensembl ID		ENSG00000163093	ENSG00000143387
Uniprot IDs		A0A0S2Z626 Q8N3I7	P43235
PDB IDs		6XTB	1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 4N79 4N8W 4X6H 4X6I 4X6J 4YV8 4YVA 5J94 5JA7 5JH3 5TDI 5TUN 5Z5O 6ASH 6HGY 6PXF 6QBS 6QL8 6QLM 6QLW 6QLX 6QM0 7PCK
Enriched GO Terms of Interacting Partners?
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