CTSK and SERPINB3

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CTSK	SERPINB3
Description		cathepsin K	serpin family B member 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Lysosome Apical Plasma Membrane Endolysosome Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoplasmic Vesicle Vesicle Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Proteoglycan Binding	Virus Receptor Activity Protease Binding Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity
	Biological Process	Autophagy Of Mitochondrion Toll-like Receptor Signaling Pathway Proteolysis Thyroid Hormone Generation Immune Response Extracellular Matrix Disassembly Collagen Catabolic Process Regulation Of Keratinocyte Differentiation Proteolysis Involved In Cellular Protein Catabolic Process	Positive Regulation Of Cell Population Proliferation Negative Regulation Of Peptidase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Endopeptidase Activity Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Autocrine Signaling Paracrine Signaling Negative Regulation Of Catalytic Activity Neutrophil Degranulation Negative Regulation Of JUN Kinase Activity Negative Regulation Of Proteolysis Viral Entry Into Host Cell
Pathways		Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Neutrophil degranulation
Drugs		[1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]Pentylcarbamate Cyanamide 3-amino-5-phenylpentane N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamide N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamide N-[(2S)-4-Methyl-1-oxo-1-{[(4S)-3-oxo-1-(2-pyridinylsulfonyl)-4-azepanyl]amino}-2-pentanyl]-1-benzofuran-2-carboxamide Dibenzyl (carbonylbis{2,1-hydrazinediyl[(2S)-4-methyl-1-oxo-1,2-pentanediyl]})biscarbamate N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide (2R)-2-(3-Biphenylyl)-N-{(2R)-2-hydroxy-3-[(2-pyridinylsulfonyl)amino]propyl}-4-methylpentanamide Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate MIV-701 Relacatib Odanacatib 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine (2R)-3-Methyl-1-phenyl-2-butanyl [(2S)-1-oxo-2-hexanyl]carbamate 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE (1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamide TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE MIV-711	D-Serine Dexfosfoserine
Diseases		Pycnodysostosis
GWAS		Blood protein levels ( 28240269) Body mass index ( 26426971) Congenital left-sided heart lesions ( 26965164) Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		6 interacting genes: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC	6 interacting genes: CDC42 CTSK CTSL CTSS MAPK8 UCHL5
Entrez ID		1513	6317
HPRD ID		03064	02745
Ensembl ID		ENSG00000143387	ENSG00000057149
Uniprot IDs		P43235	P29508
PDB IDs		1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 4N79 4N8W 4X6H 4X6I 4X6J 4YV8 4YVA 5J94 5JA7 5JH3 5TDI 5TUN 5Z5O 6ASH 6HGY 6PXF 6QBS 6QL8 6QLM 6QLW 6QLX 6QM0 7PCK	2ZV6 4ZK0 4ZK3
Enriched GO Terms of Interacting Partners?
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