COL9A1 and COMP

Data Source:
HPRD (in vitro)

		COL9A1	COMP
Description		collagen type IX alpha 1 chain	cartilage oligomeric matrix protein
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GO Annotations	Cellular Component	Extracellular Region Collagen Type IX Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Animal Organ Morphogenesis Extracellular Matrix Organization	Skeletal System Development Chondrocyte Development Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Protein Secretion Animal Organ Morphogenesis Multicellular Organism Aging Animal Organ Senescence Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Muscle Fiber Development Artery Morphogenesis Musculoskeletal Movement Neuromuscular Process Limb Development Platelet Aggregation Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization	Integrin cell surface interactions ECM proteoglycans
Drugs			Calcium
Diseases			Pseudoachondroplasia (PSACH) Multiple epiphyseal dysplasia (MED)
GWAS			Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)
Interacting Genes		2 interacting genes: COMP MAG	10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB
Entrez ID		1297	1311
HPRD ID		00367	02632
Ensembl ID		ENSG00000112280	ENSG00000105664
Uniprot IDs		P20849	P49747
PDB IDs		2UUR 5CTD 5CTI 5CVA 5CVB	3FBY
Enriched GO Terms of Interacting Partners?
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