ADH1C and PKD2

Data Source:
HPRD (in vitro)

		ADH1C	PKD2
Description		alcohol dehydrogenase 1C (class I), gamma polypeptide	polycystin 2, transient receptor potential cation channel
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Polycystin Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Lamellipodium Cytoplasmic Vesicle Membrane Motile Cilium Filamentous Actin Cation Channel Complex Ciliary Basal Body Basal Cortex Ciliary Membrane Extracellular Exosome Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Mitotic Spindle Non-motile Cilium
	Molecular Function	Alcohol Dehydrogenase (NAD+) Activity Alcohol Dehydrogenase Activity, Zinc-dependent Retinol Dehydrogenase Activity Zinc Ion Binding	Signaling Receptor Binding Voltage-gated Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Outward Rectifier Potassium Channel Activity Voltage-gated Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Ion Channel Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding
	Biological Process	Ethanol Oxidation Retinol Metabolic Process Retinoic Acid Metabolic Process	Branching Involved In Ureteric Bud Morphogenesis Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Calcium Ion Transport Cell Cycle Arrest Receptor Signaling Pathway Via JAK-STAT Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Population Proliferation Cytoplasmic Sequestering Of Transcription Factor Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Positive Regulation Of Cell Cycle Arrest Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Cell-cell Signaling By Wnt Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		RA biosynthesis pathway Ethanol oxidation	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs		NADH Fomepizole 2,3,4,5,6-Pentafluorobenzyl Alcohol N-1-methylheptylformamide 2-Ethoxyethanol Cholic Acid 4-Iodopyrazole Pyrazole Para-Bromobenzyl Alcohol 3-Butylthiolane 1-Oxide 5-beta-D-ribofuranosylnicotinamide adenine dinucleotide (R)-N-(1-Methyl-Hexyl)-Formamide Trifluoroethanol Cyclohexylformamide Cpad N-Formylpiperidine 2,3-Difluorobenzyl Alcohol 2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene
Diseases			Polycystic kidney disease
GWAS		Alcohol consumption ( 28937693 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol consumption in current drinkers ( 28937693) Alcohol consumption over the past year ( 29058377) Alcohol dependence ( 24166409 23456092 28714907 22004471) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813) Alcohol use disorder (total score) ( 30336701) Bitter alcoholic beverage consumption ( 31046077) Cerebrospinal fluid clusterin levels ( 26545630) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Hematocrit ( 32888494) Lung cancer ( 28604730) Oral cavity and pharyngeal cancer ( 21437268 27749845) Regular attendance at a pub or social club ( 29970889) Total cholesterol levels ( 30275531)	Coffee consumption (cups per day) ( 25288136) Dental caries ( 23064961) Gout ( 30899057) Hyperuricemia ( 28776340) Serum uric acid levels in response to allopurinol in gout ( 25676789) Uric acid levels ( 29558500)
Interacting Genes			21 interacting genes: ACTN2 CD2AP CYSRT1 DIAPH1 HAX1 HSF2BP KRT40 KRTAP10-3 KRTAP10-8 KRTAP6-2 LMNA MAGEA8 MDFI PACS1 PACS2 PKD1 PLSCR1 PTPRG TNNI3 TPM1 TRPC1
Entrez ID		126	5311
HPRD ID		00066	01437
Ensembl ID		ENSG00000248144	ENSG00000118762
Uniprot IDs		P00326	Q13563 Q9UEU6
PDB IDs		1DDA 1HT0 1U3W	2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O 6WB8
Enriched GO Terms of Interacting Partners?
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