MICOS13 and DIABLO

Data Source:
BioGRID (two hybrid)

		MICOS13	DIABLO
Description		mitochondrial contact site and cristae organizing system subunit 13	diablo IAP-binding mitochondrial protein
Image		No pdb structure
GO Annotations	Cellular Component	SAM Complex Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Crista Junction MICOS Complex MIB Complex	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Inner Mitochondrial Membrane Organization Cristae Formation	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway
Pathways		Cristae formation	Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS
Interacting Genes		10 interacting genes: ACSF2 APOC1 APOC2 APOC4 DIABLO HSFX1 HSFX2 PBX3 RHBDD2 TEX44	42 interacting genes: AGTRAP APOC2 APOC4 AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 CMTM4 DERL2 DGAT2L6 DHRS1 E2F1 EEF1A1 FADS6 FKBP7 HSD17B13 HTRA2 LTBR MAML2 MICOS13 MPC2 NR4A1 RHBDD2 RMDN2 SEC22A SFT2D1 SLC17A9 SLC25A47 SLC66A2 STMN4 SYP TIMMDC1 UBE2K UFM1 XIAP ZNF746
Entrez ID		125988	56616
HPRD ID		15198	05560
Ensembl ID		ENSG00000174917	ENSG00000184047
Uniprot IDs		A0A140TA84 A0A140TA86 Q5XKP0	A0A024RBT2 A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28
PDB IDs			1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5 6JX6
Enriched GO Terms of Interacting Partners?
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