ZPBP2 and RFFL

Data Source:
BioGRID (affinity chromatography technology)

		ZPBP2	RFFL
Description		zona pellucida binding protein 2	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Zona Pellucida Receptor Complex Extracellular Region Nucleus Cell Body	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane
	Molecular Function		Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Acrosome Assembly Negative Regulation Of Immunoglobulin Production Sphingolipid Metabolic Process Binding Of Sperm To Zona Pellucida Circadian Regulation Of Gene Expression Membrane Lipid Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways			Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Allergic rhinitis ( 30013184) Asthma ( 31959851 27182965 31619474 28461288) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 29273806) Asthma (time to onset) ( 27130862) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737 29892015) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Fractional exhaled nitric oxide (childhood) ( 24315451) Inflammatory bowel disease ( 28067908 23128233) Neurociticism ( 29500382) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 30572963) Subcutaneous adipose tissue ( 27918534) Systemic sclerosis ( 30572963) Ulcerative colitis ( 28067908 20228799 21297633)	Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes			21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		124626	117584
HPRD ID		18365	11489
Ensembl ID		ENSG00000186075	ENSG00000092871
Uniprot IDs		Q6X784	Q8WZ73
PDB IDs			1Y02
Enriched GO Terms of Interacting Partners?
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