AEBP2 and TSPYL2

Data Source:
BioGRID (two hybrid)

		AEBP2	TSPYL2
Description		AE binding protein 2	TSPY like 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm ESC/E(Z) Complex	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Metal Ion Binding	RDNA Binding Chromatin Binding Protein Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic	Nucleosome Assembly Cell Cycle Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth IRE1-mediated Unfolded Protein Response Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity
Pathways		PRC2 methylates histones and DNA PKMTs methylate histone lysines	XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Chronic mountain sickness ( 31417607) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Manganese levels ( 26025379) Obesity-related traits ( 23251661) Opioid use cessation ( 31936517) Pulmonary function ( 21946350) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		18 interacting genes: APP EED H1-1 H1-2 HMBOX1 JMJD6 KRTAP10-8 LDOC1 MDFI PICK1 RALYL RBBP4 SUZ12 THAP1 TRIM55 TRIM63 TSPYL2 ZNF408	46 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 EEF1A1 GFI1B H2BC15 HMGXB4 INO80B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B ZBTB24 ZBTB48 ZFP1 ZFP91 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835
Entrez ID		121536	64061
HPRD ID		16477	06713
Ensembl ID		ENSG00000139154	ENSG00000184205
Uniprot IDs		Q6ZN18	Q9H2G4
PDB IDs		5WAI 5Y0U 5Y1U 6C23 6C24
Enriched GO Terms of Interacting Partners?
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