AP2M1 and JADE1

Data Source:
BioGRID (genetic interference)

		AP2M1	JADE1
Description		adaptor related protein complex 2 subunit mu 1	jade family PHD finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle Extracellular Exosome	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome Cytoplasm Plasma Membrane Nuclear Speck Ciliary Basal Body
	Molecular Function	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Ion Channel Binding Low-density Lipoprotein Particle Receptor Binding	Transcription Coactivator Activity Protein Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Cellular Protein-containing Complex Assembly Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis Regulation Of Vesicle Size Negative Regulation Of Protein Localization To Plasma Membrane	Apoptotic Process Negative Regulation Of Cell Growth Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	HATs acetylate histones
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Arterial stiffness index ( 31235810) Bone mineral density (total hip) ( 29883787)
Interacting Genes		76 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD3D CDK11B CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HTR6 IKZF1 KCNJ11 KNOP1 LAMP1 LTB4R2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TMA16 UBC UTP25 ZBTB8A ZNF581	15 interacting genes: AKT1 CTNNB1 H3C14 H4C1 HMOX2 PFDN1 SEPTIN8 SMN1 TK1 UBE2E1 UBE2H UBE3A VHL YJU2 ZNF148
Entrez ID		1173	79960
HPRD ID		03014	10151
Ensembl ID		ENSG00000161203	ENSG00000077684
Uniprot IDs		B4DNB9 E9PFW3 Q96CW1	B4E2E2 Q6IE81
PDB IDs		1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?
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