CIB3 and SLPI

Data Source:
BioGRID (two hybrid)

		CIB3	SLPI
Description		calcium and integrin binding family member 3	secretory leukocyte peptidase inhibitor
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Golgi Apparatus Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process		Immune Response Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Modulation Of Process Of Other Organism Neutrophil Degranulation Negative Regulation Of Viral Genome Replication Innate Immune Response
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576 28240269) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)
Interacting Genes		53 interacting genes: ARMC8 BEND7 C17orf50 ENOX2 GMCL1 KASH5 KLF17 LNX1 MEOX1 MEOX2 NANOS3 NME4 PAX5 PAX6 POLR2G POU6F2 RBAK REL SCNM1 SERTAD1 SLPI SP3 SP4 SYPL1 TACC3 TLE5 TRAF5 TRIM14 TRIM2 ZBTB43 ZC2HC1C ZFP1 ZFP57 ZNF146 ZNF177 ZNF180 ZNF19 ZNF276 ZNF317 ZNF329 ZNF398 ZNF426 ZNF552 ZNF559-ZNF177 ZNF578 ZNF597 ZNF620 ZNF664 ZNF688 ZNF774 ZNF835 ZSCAN4 ZSCAN5A	25 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2
Entrez ID		117286	6590
HPRD ID		16713	00121
Ensembl ID		ENSG00000141977	ENSG00000124107
Uniprot IDs		Q96Q77	P03973
PDB IDs			2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?
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