AGAP1 and UGT1A3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		AGAP1	UGT1A3
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	UDP glucuronosyltransferase family 1 member A3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding	Retinoic Acid Binding Glucuronosyltransferase Activity Enzyme Binding Protein Homodimerization Activity
	Biological Process	Protein Transport Positive Regulation Of GTPase Activity	Estrogen Metabolic Process Bile Acid Secretion Retinoic Acid Metabolic Process Cellular Glucuronidation Flavonoid Glucuronidation Xenobiotic Glucuronidation Vitamin D3 Metabolic Process
Pathways			Glucuronidation NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Bilirubin levels ( 32084209) Hair greying ( 26926045) Liver disease biomarker ( 30576415) Low density lipoprotein cholesterol levels ( 32154731) Serum metabolite levels ( 23093944) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		14 interacting genes: APP ARF1 ARF6 CDC42 GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 ZNF534
Entrez ID		116987	54659
HPRD ID		16359	07566
Ensembl ID		ENSG00000157985	ENSG00000243135
Uniprot IDs		B2RZG9 Q9UPQ3 X5D293	P35503 Q5DT01
PDB IDs
Enriched GO Terms of Interacting Partners?
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