APOA5 and CMTM6

Data Source:
BioGRID (two hybrid)

		APOA5	CMTM6
Description		apolipoprotein A5	CKLF like MARVEL transmembrane domain containing 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron	Plasma Membrane Membrane Integral Component Of Membrane Early Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane
	Molecular Function	Protein Binding Phospholipid Binding Enzyme Activator Activity Heparin Binding Lipid Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipase Activator Activity Lipoprotein Lipase Activator Activity Lipoprotein Particle Receptor Binding	Protein Binding
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Lipid Transport Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Lipid Metabolic Process Triglyceride Catabolic Process Regulation Of Intestinal Cholesterol Absorption Cholesterol Efflux Phospholipid Efflux Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Tissue Regeneration Cholesterol Homeostasis Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Lipoprotein Lipase Activity Acylglycerol Homeostasis Triglyceride Homeostasis	Protein Transport Regulation Of Protein Stability Endocytic Recycling Neutrophil Degranulation
Pathways		PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling	Neutrophil degranulation
Drugs
Diseases		Hyperlipoproteinemia, type V
GWAS		Apolipoprotein A1 levels ( 32203549) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488) Body mass index ( 31978080) Cardiovascular risk factors (age interaction) ( 20838585) Carotenoid and tocopherol levels ( 19185284) Cholesterol, total ( 19060911 26780889 20686565) Coronary artery disease ( 32469254 29263402 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 28371326 20864672 19060906 21347282 26780889 20686565 26582766 29212154) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 31694877 28334899 26690388) Hematocrit ( 29403010) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30718733) Hypertriglyceridemia ( 31910446 27599772 23505323 20657596) LDL cholesterol ( 18179892 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095 24023260) Low HDL-cholesterol levels ( 31910446) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Mean corpuscular volume ( 29403010) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31910446 30382898 21386085 31170924 28371326 29212154) Metabolite levels ( 23823483 22916037) Multiple sclerosis ( 31604244) NHDL cholesterol to HDL cholesterol ratio ( 28046027) Obesity-related traits ( 23251661) Phosphatidylinositol levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Platelet count ( 29403010) Postprandial triglyceride levels ( 32603185) Response to Vitamin E supplementation ( 22437554) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 29403010 29615537 30275531) Triacylglyceride levels ( 31551469) Triglyceride levels ( 30718733 28334899 26763881 32154731 28371326 29403010 29615537 32335043 29212154) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 24097068 19074352 29404214 21909109 18193043 18193044 20864672 26160806 19060906 19060911 22171074 20139978 26780889 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)	Apolipoprotein B levels ( 32203549) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Cholesterol, total ( 24097068) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 28334899) Low density lipoprotein cholesterol levels ( 32154731) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		16 interacting genes: ACSF2 BMP10 CMTM3 CMTM5 CMTM6 FAS MORN4 MYG1 RAB5B SELENOS SMARCD1 TMEM120B TMEM19 TMEM43 TTPA YIF1A	23 interacting genes: APOA5 ATP13A2 BPIFA2 CD160 CD40 CIAO2A COQ8A DNMT3B DUSP10 ECPAS EHHADH FAM9B MIEF1 PPBP RBFA RBMX RUSC1 SNRPB2 SPG21 SUMO2 TCEA2 TMED8 XRCC6
Entrez ID		116519	54918
HPRD ID		06966	06987
Ensembl ID		ENSG00000110243	ENSG00000091317
Uniprot IDs		A0A0B4RUS7 Q6Q788	Q9NX76
PDB IDs
Enriched GO Terms of Interacting Partners?
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