TRMT61A and TCL1A

Data Source:
BioGRID (two hybrid)

		TRMT61A	TCL1A
Description		tRNA methyltransferase 61A	TCL1 family AKT coactivator A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Nucleoplasm Endoplasmic Reticulum Cytosol Protein-containing Complex
	Molecular Function	Protein Binding TRNA (adenine-N1-)-methyltransferase Activity MRNA (adenine-N1-)-methyltransferase Activity	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	TRNA Modification TRNA Methylation MRNA Methylation	Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Branched-chain amino acid levels (Isoleucine) ( 27898682) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Mean corpuscular volume ( 32888494 27863252) Red blood cell count ( 32888494) Schizophrenia ( 25056061)	Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		2 interacting genes: TCL1A TRMT6	38 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CASP8AP2 CCDC13 CEP55 DDIT4L DNMT3A FLACC1 GOLGA2 H2AW INCA1 LNX1 LNX2 LSM3 NFKBIA NFKBID NIF3L1 NTAQ1 PPP1R13B PRTFDC1 REL TAX1BP1 TCF4 TEPSIN TNKS TP53BP2 TRAF1 TRAF2 TRMT61A TTC33 TXLNA TXLNB WDR47
Entrez ID		115708	8115
HPRD ID		08810	01744
Ensembl ID		ENSG00000166166	ENSG00000100721
Uniprot IDs		A0A024R6Q2 Q96FX7	A0A024R6G5 P56279
PDB IDs		5CCB 5CCX 5CD1	1JSG
Enriched GO Terms of Interacting Partners?
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