GPRASP2 and CHRM2

Data Source:
HPRD (in vitro)

		GPRASP2	CHRM2
Description		G protein-coupled receptor associated sorting protein 2	cholinergic receptor muscarinic 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Dendrite Clathrin-coated Vesicle Membrane Synapse Postsynaptic Membrane
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding	G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity Arrestin Family Protein Binding
	Biological Process	Hematopoietic Stem Cell Homeostasis	Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Regulation Of Heart Contraction Response To Virus Membrane Organization G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways			Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Diphenhydramine Pilocarpine Doxacurium Doxepin Flavoxate Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Acetylcholine Rapacuronium ALKS 27 Pizotifen Fesoterodine Hexocyclium Dimetindene Aclidinium Umeclidinium Trimebutine Dosulepin Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS			Copper levels ( 26025379) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) PR interval ( 32439900) Pulse pressure ( 30224653) Resting heart rate ( 29769521 27798624)
Interacting Genes		52 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CAVIN3 CBX8 CCDC146 CEP126 CFAP206 CHRM1 CHRM2 DISC1 EFCAB3 FAM124B FCHSD2 FOXD4L1 FRAT1 GADD45GIP1 HAP1 HRH2 HTR7 HTT LRIF1 MBD3L2 MICU2 MYOT NOL4L-DT PIH1D2 PLAC9 PRPF3 PTN RABGEF1 REX1BD RHPN1 RNF8 RPS6KA5 RTL10 SAPCD2 SEZ6L SH2D4A SREK1 STMN2 TBRG4 TCF25 TSPOAP1 TTC23 TXN TXN2 USP20 ZC2HC1C ZFYVE26 ZNF688	18 interacting genes: GJC2 GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 HERPUD1 MDH1 RGS7 SAG SET SHISA4 SLC52A2 TMEM8B TSPAN33 TSPAN7
Entrez ID		114928	1129
HPRD ID		06612	00328
Ensembl ID		ENSG00000158301	ENSG00000181072
Uniprot IDs		B3KW05 Q96D09	A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1
PDB IDs			1LUB 3UON 4MQS 4MQT 5YC8 5ZK3 5ZK8 5ZKB 5ZKC 6OIK 6U1N
Enriched GO Terms of Interacting Partners?
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