SORCS1 and SORT1

Data Source:
BioGRID (pull down)

		SORCS1	SORT1
Description		sortilin related VPS10 domain containing receptor 1	sortilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Membrane Integral Component Of Membrane	Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Endosome Membrane Integral Component Of Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Golgi Cisterna Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Neuropeptide Receptor Activity	Protein Binding Nerve Growth Factor Receptor Activity Enzyme Binding Neurotensin Receptor Activity, Non-G Protein-coupled Nerve Growth Factor Binding Retromer Complex Binding
	Biological Process	Post-Golgi Vesicle-mediated Transport Neuropeptide Signaling Pathway	Ossification Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Endocytosis G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organism Development Endosome To Lysosome Transport Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Myotube Differentiation Vesicle Organization Endosome Transport Via Multivesicular Body Sorting Pathway Response To Insulin Nerve Growth Factor Signaling Pathway Negative Regulation Of Fat Cell Differentiation Glucose Import Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane To Endosome Transport Negative Regulation Of Lipoprotein Lipase Activity Golgi To Lysosome Transport Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways			Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Abnormal white matter microstructure in first episode schizophrenia (multivariate analysis) ( 28924203) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Benign prostatic hyperplasia ( 30988330) Circulating leptin levels in high cardiovascular risk ( 31766143) Endometriosis ( 23472165) Metabolite levels (Pyroglutamine) ( 23934736) Methadone dose in opioid dependence ( 28115739) Systemic juvenile idiopathic arthritis ( 27927641) White matter microstructure in first episode schizophrenia (left posterior cingulate cortex) ( 28924203)	Abdominal aortic aneurysm ( 27899403) Cholesterol, total ( 24097068 25961943 20686565) Chronic kidney disease ( 20383146) Cognitive ability ( 29186694) Coronary artery disease ( 21239051 24262325 26343387 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378988 21378990) Coronary heart disease x type 2 diabetes interaction ( 32541925) HDL cholesterol ( 25961943) LDL cholesterol ( 24097068 18193043 18193044 19060906 19060910 21347282 25961943 20686565) LDL cholesterol levels ( 28334899 26690388) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 30718733 31969989) Low density lipoprotein cholesterol levels (on statin treatment) ( 31969989) Metabolite levels ( 21909109) Metabolite levels (lipoprotein measures) ( 27005778) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609) Peripheral artery disease ( 31285632) Progranulin levels ( 21087763 29186428) Ratio of apolipoprotein A1 to apolipoprotein B ( 29084231) Response to statin therapy ( 20339536) Response to statins (LDL cholesterol change) ( 31969989) Response to statins (LDL cholesterol percent change) ( 31969989) Total cholesterol levels ( 28334899)
Interacting Genes		2 interacting genes: FURIN SORT1	16 interacting genes: ADGRG7 BDNF BRICD5 CNIH3 GGA1 GGA2 LRPAP1 NGF NGFR NTRK1 NTRK2 NTRK3 NTS SORCS1 SORL1 TF
Entrez ID		114815	6272
HPRD ID		12098	03910
Ensembl ID		ENSG00000108018	ENSG00000134243
Uniprot IDs		A8K182 B3KVZ0 B3KWN9 E6Y3F9 E6Y3G0 Q8WY21	Q99523
PDB IDs			3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H
Enriched GO Terms of Interacting Partners?
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