CHRNB1 and ASB6

Data Source:
BioGRID (two hybrid)

		CHRNB1	ASB6
Description		cholinergic receptor nicotinic beta 1 subunit	ankyrin repeat and SOCS box containing 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuromuscular Junction Neuron Projection Synapse Integral Component Of Postsynaptic Specialization Membrane	Cytosol
	Molecular Function	Protein Binding Channel Activity Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding
	Biological Process	Postsynaptic Membrane Organization Skeletal Muscle Contraction Cation Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Membrane Potential Muscle Fiber Development Nervous System Process Excitatory Postsynaptic Potential	Protein Ubiquitination Intracellular Signal Transduction Post-translational Protein Modification
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Congenital myasthenic syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Emotional recognition ( 31596458) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ASB6 COPS6 RAPSN	16 interacting genes: APP CHRNB1 DUSP23 FAM9B HOMEZ HOXB5 L3MBTL3 MOS POLR2A RNF41 SH2B2 TARS2 TCAP ZBTB42 ZNF587 ZNF655
Entrez ID		1140	140459
HPRD ID		01156	10673
Ensembl ID		ENSG00000170175	ENSG00000148331
Uniprot IDs		P11230	F6TX30 Q9NWX5
PDB IDs
Enriched GO Terms of Interacting Partners?
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