TMEM54 and RBBP8

Data Source:
BioGRID (two hybrid)

		TMEM54	RBBP8
Description		transmembrane protein 54	RB binding protein 8, endonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Integral Component Of Membrane	Nucleus Nucleoplasm Transcription Repressor Complex Site Of Double-strand Break Intracellular Membrane-bounded Organelle
	Molecular Function	Molecular_function Protein Binding	Single-stranded DNA Endodeoxyribonuclease Activity Y-form DNA Binding Double-strand/single-strand DNA Junction Binding RNA Polymerase II Repressing Transcription Factor Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Protein Binding Identical Protein Binding Flap-structured DNA Binding
	Biological Process	Biological_process	Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Negative Regulation Of Transcription, DNA-templated Cell Division Meiotic Cell Cycle Negative Regulation Of G0 To G1 Transition Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination
Drugs
Diseases			Seckel syndrome
GWAS		Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)	Eosinophil percentage of white cells ( 27863252) Height ( 25429064 18391951) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014)
Interacting Genes		24 interacting genes: ARL13B CD3G CLSTN3 CREB3 FKBP7 GPR152 GPR37L1 KCNJ8 KCNK5 KLRC1 LMNA MS4A14 NRG1 PEX19 PSCA PVR RBBP8 SERINC2 SLC12A7 SLC39A2 TIMMDC1 TMEM52B TSPO2 UPK1B	37 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 EEF1A1 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PCNA PIN1 PRKDC PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 USP4
Entrez ID		113452	5932
HPRD ID		12524	04990
Ensembl ID		ENSG00000121900	ENSG00000101773
Uniprot IDs		Q969K7	A0A024RC34 Q99708
PDB IDs			2L4Z 4D2H
Enriched GO Terms of Interacting Partners?
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