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RBBP8 and TMEM54
Data Source:
BioGRID
(two hybrid)
RBBP8
TMEM54
Description
RB binding protein 8, endonuclease
transmembrane protein 54
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Repressor Complex
Site Of Double-strand Break
Intracellular Membrane-bounded Organelle
Cellular_component
Integral Component Of Membrane
Molecular Function
Single-stranded DNA Endodeoxyribonuclease Activity
Y-form DNA Binding
Double-strand/single-strand DNA Junction Binding
RNA Polymerase II Repressing Transcription Factor Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Corepressor Activity
Protein Binding
Identical Protein Binding
Flap-structured DNA Binding
Molecular_function
Protein Binding
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Repair
Regulation Of Transcription By RNA Polymerase II
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Negative Regulation Of Transcription, DNA-templated
Cell Division
Meiotic Cell Cycle
Negative Regulation Of G0 To G1 Transition
Nucleic Acid Phosphodiester Bond Hydrolysis
Regulation Of Signal Transduction By P53 Class Mediator
Biological_process
Pathways
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Transcriptional Regulation by E2F6
Meiotic recombination
Drugs
Diseases
Seckel syndrome
GWAS
Eosinophil percentage of white cells (
27863252
)
Height (
25429064
18391951
)
Intracranial aneurysm (
20364137
)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) (
27418160
)
Late-onset myasthenia gravis (
26562150
)
Lung function (FEV1) (
30061609
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Scalp hair shape (
26926045
)
Tuberculosis (
20694014
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Interacting Genes
37 interacting genes:
ATM
BARD1
BRCA1
CLU
CTBP1
CUL3
DNA2
EEF1A1
FXR2
FZR1
HID1
IGFBP7
IKBKG
IKZF1
IKZF3
KLHL15
LIMS1
LMO1
LMO2
LMO4
MAP2K4
NTAQ1
PCNA
PIN1
PRKDC
PRRG4
RAF1
RB1
RBL1
RBL2
RGS17
SIAH1
SIAH2
TGIF2
TMEM54
TOPBP1
USP4
24 interacting genes:
ARL13B
CD3G
CLSTN3
CREB3
FKBP7
GPR152
GPR37L1
KCNJ8
KCNK5
KLRC1
LMNA
MS4A14
NRG1
PEX19
PSCA
PVR
RBBP8
SERINC2
SLC12A7
SLC39A2
TIMMDC1
TMEM52B
TSPO2
UPK1B
Entrez ID
5932
113452
HPRD ID
04990
12524
Ensembl ID
ENSG00000101773
ENSG00000121900
Uniprot IDs
A0A024RC34
Q99708
Q969K7
PDB IDs
2L4Z
4D2H
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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