ECD and TET2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ECD	TET2
Description		ecdysoneless cell cycle regulator	tet methylcytosine dioxygenase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus
	Molecular Function	Protein Binding Histone Acetyltransferase Binding	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity
	Biological Process	MRNA Processing RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II	5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Histone H3-K4 Trimethylation
Pathways			TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic obstructive pulmonary disease ( 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte counts ( 29403010 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of white cells ( 32888494 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Platelet count ( 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Self-reported risk-taking behaviour ( 30271922) Tonsillectomy ( 27182965 28928442) Western dietary pattern ( 28644415)
Interacting Genes		6 interacting genes: CSNK2A1 EWSR1 NR3C1 PSEN2 TET2 TXNIP	19 interacting genes: DCAF1 ECD EIF2B2 HLF HOXB9 KEAP1 MED1 MNAT1 OGT PHC1 PKNOX1 RAI1 SMAD1 STAT5A TBC1D4 TFEC VPS72 ZCCHC14 ZNF207
Entrez ID		11319	54790
HPRD ID		11032	07876
Ensembl ID		ENSG00000122882	ENSG00000168769
Uniprot IDs		O95905	A0A024RDF7 A0A158SIU0 Q6N021
PDB IDs			4NM6 5D9Y 5DEU
Enriched GO Terms of Interacting Partners?
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