TET2 and ZCCHC14

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TET2	ZCCHC14
Description		tet methylcytosine dioxygenase 2	zinc finger CCHC-type containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus
	Molecular Function	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity	Nucleic Acid Binding Protein Binding Zinc Ion Binding Phosphatidylinositol Binding
	Biological Process	5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Histone H3-K4 Trimethylation
Pathways		TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic obstructive pulmonary disease ( 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte counts ( 29403010 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of white cells ( 32888494 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Platelet count ( 32888494) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Self-reported risk-taking behaviour ( 30271922) Tonsillectomy ( 27182965 28928442) Western dietary pattern ( 28644415)	Broad depression or schizophrenia ( 30626913) Hippocampal volume in mild cognitive impairment ( 29274321) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Major depressive disorder ( 22472876) Migraine ( 27182965 27322543) Neuroticism ( 29255261) Refractive error ( 32231278) Small vessel stroke ( 27997041) Stroke ( 29531354)
Interacting Genes		19 interacting genes: DCAF1 ECD EIF2B2 HLF HOXB9 KEAP1 MED1 MNAT1 OGT PHC1 PKNOX1 RAI1 SMAD1 STAT5A TBC1D4 TFEC VPS72 ZCCHC14 ZNF207	16 interacting genes: CYSRT1 FHL3 MYO15B MYOG NFIC PLEKHG4 PRR20A PRR20B PRR20C PRR20D PRR20E SMAD3 TENT4B TET2 TNS2 USP54
Entrez ID		54790	23174
HPRD ID		07876	18316
Ensembl ID		ENSG00000168769	ENSG00000140948
Uniprot IDs		A0A024RDF7 A0A158SIU0 Q6N021	Q8WYQ9
PDB IDs		4NM6 5D9Y 5DEU
Enriched GO Terms of Interacting Partners?
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