SGF29 and MED4

Data Source:
BioGRID (two hybrid)

		SGF29	MED4
Description		SAGA complex associated factor 29	mediator complex subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	SAGA Complex Ada2/Gcn5/Ada3 Transcription Activator Complex SAGA-type Complex	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding Enzyme Binding Methylated Histone Binding Protein N-terminus Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Histone Acetylation Histone H3 Acetylation Establishment Of Protein Localization To Chromatin	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways		HATs acetylate histones	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS			Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		30 interacting genes: BECN1 C20orf202 CCDC102B CCDC158 CLHC1 DBF4B H3-4 KNSTRN KRT13 KRT15 KRT16 KRT19 KRT24 KRT27 KRT33B LNX1 LZTS1 MED11 MED4 MYF5 NDC80 PROSER3 RINT1 SYCE3 SYNPO TADA3 TCF4 TEX12 TFIP11 TRAF3IP1	41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 SYCE2 TLE5 TNFAIP8 TNFAIP8L1 TXLNA TXLNB USHBP1 WDTC1
Entrez ID		112869	29079
HPRD ID		13996	16145
Ensembl ID		ENSG00000176476	ENSG00000136146
Uniprot IDs		Q96ES7	A0A024RDY7 Q9NPJ6
PDB IDs		3LX7 3ME9 3MEA 3MET 3MEU 3MEV 3MEW 5C0M
Enriched GO Terms of Interacting Partners?
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