MED4 and CCHCR1

Data Source:
BioGRID (two hybrid, two hybrid)

		MED4	CCHCR1
Description		mediator complex subunit 4	coiled-coil alpha-helical rod protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Nucleus Centriole Cytosol
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Protein Export From Nucleus Multicellular Organism Development Cell Differentiation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Feeling nervous ( 29500382) Head and neck squamous cell carcinoma ( 32276964) Hematology traits ( 23263863) Hemoglobin ( 32888494) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Microalbuminuria ( 31511532) Monocyte percentage of white cells ( 32888494) Multiple myeloma ( 23955597) Nevirapine-induced rash ( 21810746) Night sleep phenotypes ( 27126917) Prostate cancer ( 21743467) Psoriasis ( 30921485) Reticulocyte count ( 32888494) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) White blood cell count ( 21738480)
Interacting Genes		41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 SYCE2 TLE5 TNFAIP8 TNFAIP8L1 TXLNA TXLNB USHBP1 WDTC1	165 interacting genes: ABI1 ABI2 ALAS1 AMOTL2 ANKRD11 ATG5 BFSP1 BICD2 BLOC1S2 BLOC1S6 BORCS6 C1orf109 C1orf94 CARD9 CBY2 CCDC102B CCDC13 CCDC136 CCDC197 CCDC33 CCDC88B CCNC CDC37 CDR2 CDR2L CDSN CEP55 CEP57 CEP63 CFAP53 CNN1 CNOT2 COG6 CRACR2A CTAG1A CTAG1B DEUP1 DISC1 DMAP1 DTNB DYDC1 EFHC2 EXOC1 EXOC4 EXOC7 EXOC8 FSD2 GAS8 GLRX3 GNG13 GOLGA2 GOLGA6L9 GRAP2 HAUS1 HAUS8 HDDC3 HGFAC HOMEZ HSBP1 HSF2BP HSPB1 IFT20 IKBKG IKZF3 ING5 IQCC KIAA0753 KIFC3 KRT13 KRT15 KRT16 KRT18 KRT19 KRT24 KRT27 KRT31 KRT34 KRT35 KRT36 KRT40 KRT75 LENG1 LHX8 LZTS1 MAD1L1 MBD3 MCRS1 MED4 MIA2 MID2 MTUS2 NAB2 NDC80 NFKBID NINL NME7 NTAQ1 NUP54 NUP62 NUTM1 OIP5 PCM1 PFDN6 PIAS2 PIBF1 PKP2 PLEKHA7 POLD2 POLR2C POU6F2 PPP1R13B PRDM6 PRKCG PROSER3 RABGEF1 RALBP1 RBM17 RBM41 RCOR3 RINT1 RUSC1 SAMD11 SAT1 SMARCE1 SORBS3 SPAG5 SPG21 SSX2IP STAR STARD4 STMN2 STX11 SYCE1 SYCE1L TACC3 TADA2A TEKT1 TEX33 TEX9 TFIP11 TPM1 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TRIM54 TRIML2 TSG101 TSGA10 TSHZ3 TXLNA TXLNB USHBP1 VPS52 VPS9D1 WASHC3 ZBTB16 ZFYVE19 ZGPAT ZNF620 ZNF629 ZNF655 ZNF774 ZWINT
Entrez ID		29079	54535
HPRD ID		16145	05607
Ensembl ID		ENSG00000136146	ENSG00000204536
Uniprot IDs		A0A024RDY7 Q9NPJ6	A0A1U9X7G6 Q2TB68 Q769H0 Q8TD31
PDB IDs
Enriched GO Terms of Interacting Partners?
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