CHRM1 and CDC14A

Data Source:
BioGRID (enzymatic study)

		CHRM1	CDC14A
Description		cholinergic receptor muscarinic 1	cell division cycle 14A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Axon Terminus Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Cholinergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Spindle Pole Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Nuclear Body Stereocilium Tip Kinocilium Mitotic Spindle Kinociliary Basal Body
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Nervous System Development Regulation Of Locomotion Positive Regulation Of Ion Transport Saliva Secretion Cognition Regulation Of Postsynaptic Membrane Potential Regulation Of Glial Cell Proliferation Positive Regulation Of Intracellular Protein Transport G Protein-coupled Serotonin Receptor Signaling Pathway	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Regulation Of Exit From Mitosis Sensory Perception Of Sound Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Cell Division Cilium Assembly Mitotic Cell Cycle Arrest
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase MAPK6/MAPK4 signaling
Drugs		Cevimeline Tramadol Succinylcholine Trospium Oxyphenonium Benzatropine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Buclizine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Promazine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Amoxapine Cinnarizine Atropine Nicardipine Pirenzepine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Clidinium Propiomazine Propantheline Dicyclomine Minaprine Tropicamide Biperiden Brompheniramine Flupentixol Cocaine Maprotiline Methantheline Cycrimine Cyclopentolate Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Flavoxate Desipramine Escitalopram Ketamine Quetiapine Diphenidol Metoclopramide Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Molindone Staurosporine Acetylcholine Arecoline Mepenzolate NGX267 ALKS 27 ACP-104 Pizotifen Fesoterodine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Etoperidone Imidafenacin Pyrantel Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Urate levels ( 31578528)	Estimated glomerular filtration rate ( 31152163 31015462) Systolic blood pressure x educational attainment (some college) interaction (2df) ( 32372009)
Interacting Genes		5 interacting genes: CDC14A GNAI2 GPRASP1 GPRASP2 RGS7	15 interacting genes: AATK ATPAF2 BRAP C14orf119 CDC25B CDC6 CHRM1 FZR1 KIF20A LMTK2 PLK1 POLR2A PTK7 ROR2 TP53
Entrez ID		1128	8556
HPRD ID		00338	04614
Ensembl ID		ENSG00000168539	ENSG00000079335
Uniprot IDs		P11229 Q53XZ3	A0A0U1RQX7 A0A2R8YDJ8 B4DY86 Q59EF4 Q9UNH5
PDB IDs		5CXV 6OIJ 6WJC
Enriched GO Terms of Interacting Partners?
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