DCTN3 and DCTN1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DCTN3	DCTN1
Description		dynactin subunit 3	dynactin subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleolus Centrosome Spindle Cytosol Dynactin Complex Microtubule Midbody Cleavage Furrow Perinuclear Region Of Cytoplasm	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Microtubule Plus-end Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage
	Molecular Function	Structural Molecule Activity Protein Binding	Motor Activity Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding Microtubule Plus-end Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoskeleton-dependent Cytokinesis Ciliary Basal Body-plasma Membrane Docking	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Nuclear Migration Nervous System Development Neuromuscular Junction Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome IRE1-mediated Unfolded Protein Response Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Envelope Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Ciliary Basal Body-plasma Membrane Docking Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Perry syndrome Distal hereditary motor neuropathies (dHMN)
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: ATXN1 DCTN1 GSK3B KRT34 NUP54 PBX2 PITX1 TRIM55 TRIP13 USHBP1 VPS37C	46 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 ENO3 FBXL5 GRB2 GSK3B HAP1 HSPB2 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TP53RK VIM ZNF512B
Entrez ID		11258	1639
HPRD ID		06303	07206
Ensembl ID		ENSG00000137100	ENSG00000204843
Uniprot IDs		O75935 X6RLR1	Q14203 Q6MZZ3
PDB IDs			1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?
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